目的 探讨健康儿童睁眼和闭眼不同状态下的多频段大脑磁活动特征。方法 记录24名健康儿童睁眼和闭眼时的脑磁图数据。应用累积源成像方法,对大脑磁活动在多个频段进行分析,包括δ（1~4 Hz）、 θ（4~8 Hz）、α（8~12 Hz）、β（12~30 Hz）、低γ（30~55 Hz）和高γ（65~90 Hz）频段。结果 纳入研究24名,平均年龄（10.3±2.4）岁,男14名、女10名。闭眼状态组儿童的α和β频段脑磁源绝对强度较睁眼状态组显著增加,差异有统计学意义（P<0.01）。与睁眼状态组相比,闭眼状态组儿童α和β频段脑磁源相对强度显著升高,差异有统计学意义（P<0.01）。闭眼状态组的δ、低γ和高γ频段脑磁源相对强度较睁眼状态组显著降低,差异有统计学意义（P<0.05）。各频段的脑磁源位置分布在睁、闭眼状态下差异无统计学意义（P>0.05）。结论 睁眼和闭眼状态下,大脑活动在较宽的频率范围内发生显著变化。闭眼可以调节多种频率范围内的大脑生理活动。在脑磁图或脑电图的研究中,应考虑睁眼闭眼的基线条件差异。

Objective To investigate the characteristics of brain activities within multi-frequency ranges in the developing brain during eyes-open and eyes-closed. Methods The magnetoencephalography (MEG) data were recorded from 24 healthy children during eyes-open and eyes-closed. The MEG sources were localized with accumulated source imaging and analyzed in multi-frequency bands, including delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-30 Hz), low-gamma (30-55 Hz) and high-gamma (65-90 Hz). Results Twenty-four subjects (14 boys and 10 girls) were enrolled, and the average age was (10.3±2.4) years. Compared with eyes-open, the absolute source power of alpha and beta activities during eyes-closed was increased in children, and the difference was statistically significant (P<0.01). Compared with eyes-open, the relative source power of alpha and beta activities was increased (P<0.01), while the relative source power of delta, low-gamma and high-gamma activities was decreased during eyes-closed in children, and the differences were statistically significant (P<0.05). There was no significant difference in the source location distribution of each frequency band between eyes-open and eyes-closed in children (P>0.05). Conclusions The brain activity varies significantly over a wide frequency range between eyes-open and eyes-closed in children. Eye closure can regulate brain physiological activity in a wide range of frequencies. The differences in baseline conditions between eyes-closed and eyes-open should be considered in MEG or EEG studies.