肺炎支原体肺炎与预后相关的临床指标

刘峰

doi:10.12372/jcp.2022.22e0170

临床儿科杂志 >

2022 , Vol. 40 >Issue 4: 247 - 251

DOI: https://doi.org/10.12372/jcp.2022.22e0170

专家笔谈

肺炎支原体肺炎与预后相关的临床指标

刘峰

展开

南京医科大学附属儿童医院呼吸科(江苏南京 210029)

刘峰,博士ORCID：0000-0003-2875-1909,青年编委,刘峰(1980—),博士,南京医科大学附属儿童医院呼吸科主任医师,副教授,硕士研究生导师。从事儿童呼吸系统疾病的诊断和治疗,在儿童肺炎支原体肺炎和支气管哮喘的基础和临床领域积累了一定的经验。兼任中华医学会儿科学分会转化医学委员会委员,中华医学会儿科呼吸学组青年委员,中国医师协会儿科医师分会儿童呼吸专业委员会青年委员会委员,中国医师协会儿科医师分会儿童内镜专业委员会委员,江苏省儿童呼吸学组感染协助组副组长等职。主持国家自然科学基金一项,南京市杰出青年基金一项。南京市卫生青年人才,江苏省青年医学人才。以第一作者和通讯作者发表SCI论文24篇。获江苏省科技进步二等奖一项,南京市科技进步二等奖一项,南京市科技进步三等奖一项,江苏省医学科技奖二等奖一项。

收稿日期: 2022-01-27

网络出版日期: 2022-04-07

收起

Clinical indicators related to prognosis of Mycoplasma pneumoniae pneumonia

Feng LIU

Expand

Department of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China

Received date: 2022-01-27

Online published: 2022-04-07

Fold

摘要

肺炎支原体（MP）通过对呼吸道组织造成直接损害和免疫损伤导致儿童社区获得性肺炎。目前难治性肺炎支原体肺炎（RMPP）及MPP并发症如支气管黏液栓、闭塞性细支气管炎等明显增多。因此,把握RMPP以及MPP相关并发症的预测及诊断的临床指标对于儿童疾病的预后至关重要。

关键词： 肺炎支原体肺炎; 预测; 临床指标; 儿童

本文引用格式

刘峰 . 肺炎支原体肺炎与预后相关的临床指标[J]. 临床儿科杂志, 2022 , 40(4) : 247 -251 . DOI: 10.12372/jcp.2022.22e0170

Abstract

Mycoplasma pneumoniae (MP) results in community-acquired pneumonia in children by causing direct damage and immune damage to respiratory tissue. At present, refractory Mycoplasma pneumoniae pneumonia (RMPP), MPP complications such as bronchial mucous plugs, bronchiolitis obliterans, etc., have increased significantly. Therefore, it is very important to grasp the clinical indicators for the prediction and diagnosis of RMPP and MPP-related complications for the prognosis of childhood diseases.

Key words： Mycoplasma pneumoniae pneumonia; prediction; clinical indicator; child

参考文献

[1]	Ding Y, Chu C, Li Y, et al. High expression of HMGB1 in children with refractory Mycoplasma pneumoniae pneumonia[J]. BMC Infect Dis, 2018, 18:439.
[2]	Meyer Sauteur PM, van Rossum AM, Vink C. Mycoplasma pneumoniae in children: carriage, pathogenesis, and antibiotic resistance[J]. Curr Opin Infect Dis, 2014, 27(3):220-227.
[3]	Jiang ZL, Li SH, Zhu CM, et al, Mycoplasma pneumoniae infections: pathogenesis and vaccine development[J]. Pathogens, 2021, 10(2):119.
[4]	Tamura A, Matsubara K, Tanaka T, et al. Methyl-prednisolone pulse therapy for refractory Mycoplasma pneumoniae pneumonia in children[J]. J Infect, 2008, 57(3):223-228.
[5]	卢志威, 赵辉, 郑跃杰, 等. 三种方法对儿童肺炎支原体感染诊断的动态评价[J]. 临床儿科杂志, 2012, 30(4):382-385.
[6]	Zhu Y, Wang J. Logistic regression analysis of high risk factors of mycoplasma pneumoniae pneumonia in children[J]. Hebei Med, 2018, 24:60-63.
[7]	Qu BN, Chi L, Zhu ZW, et al. Clinical characteristics and high risk factors of mycoplasma pneumoniae pneumonia in children[J]. Chin Pediatr Integrated Traditi Western Med, 2019, 11:58-62.
[8]	Liu XM, Cui ZZ, Yang G, et al. Analysis of risk factors of Mycoplasma pneumoniae pneumonia[J]. China J Modern Med, 2019, 10:1-8.
[9]	Gong Hui, Sun Baijun, Chen Ye, et al. The risk factors of children acquiring refractory mycoplasma pneumoniae pneumonia: a meta-analysis[J]. Medicine (Baltimore), 2021, 100:e24894.
[10]	Liu XF, Zhao ZM, Zhang ZP, et al. Analysis of risk factors of Mycoplasma pneumoniae pneumonia in children[J]. Hebei Med, 2017, 23:780-783.
[11]	Zhou YA. Changes of C-reactive protein in the course of mycoplasma pneumonia and its clinical significance[J]. Chin J Misdiagnosis, 2011, 11:3567-3569.
[12]	Wen J, Su Y, Sun H, et al. The combination of initial markers to predict refractory Mycoplasma pneumoniae pneumonia in Chinese children: a case control study[J]. Respir Res, 2021, 22(1):89.
[13]	Yuan SJ, Xie HT, Li ZL. Clinical significance of hypersensitive C-reactive protein, fribrinogen and D-dimmer in connective tissue disease-related interstitial lung disease[J]. Nan Fang Yi Ke Da Xue Xue Bao, 2017, 37:415-419.
[14]	Kazama I, Nakajima T. Acute bronchitis caused by bordetella pertussis possibly co-infected with Mycoplasma Pneumoniae[J]. Am J Case Rep, 2019, 20:60-64.
[15]	Tezol O, Bozlu G, Sagcan F, et al. Value of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio and red blood cell distribution width in distinguishing between reactive lymphadenopathy and lymphoma in children[J]. Bratisl Lek Listy, 2020, 121:287-292.
[16]	Balta S, Demirkol S, Kucuk U. The platelet lymphocyte ratio may be useful inflammatory indicator in clinical practice[J]. Hemodial Int, 2013, 17:668-669.
[17]	Patel N, Penkert RR, Jones BG, et al. Baseline serum vitamin A and D levels determine benefit of oral vitamin A&D supplements to humoral immune responses following pediatric influenza vaccination[J]. Viruses, 2019, 11(10):907.
[18]	Ling Y, Ning J, Xu Y. Explore the predictive value of peripheral blood cell parameters in refractory mycoplasma pneumoniae pneumonia in children over 6 years old[J]. Front Pediatr, 2021, 9:659677.
[19]	Huang X, Li D, Liu F, et al. Clinical significance of D-dimer levels in refractory Mycoplasma pneumoniae pneumonia[J]. BMC Infectious Diseases, 2021, 21(1):14.
[20]	Jain S, Williams DJ, Arnold SR, et al. Community-acquired pneumonia requiring hospitalization among U.S. children[J]. N Engl J Med, 2015, 372(9):835-845.
[21]	Gao LW, Yin J, Hu YH, et al. The epidemiology of paediatric Mycoplasma pneumoniae pneumonia in North China: 2006 to 2016[J]. Epidemiol Infect, 2019, 147:e192.
[22]	Zhang Y, Zhou Y, Li S, et al. The clinical characteristics and predictors of refractory Mycoplasma pneumoniae pneumonia in children[J]. PLoS One, 2016, 11(5):e0156465.
[23]	Bi Y, Zhu Y, Ma X, et al. Development of a scale for early prediction of refractory Mycoplasma pneumoniae pneumonia in hospitalized children[J]. Sci Rep, 2021, 11(1):6595.
[24]	Zhao Q, Zhang T, Zhu B, et al. Increasing age affected polymorphonuclear neutrophils in prognosis of Myco-plasma pneumoniae pneumonia[J]. J Inflamm Res, 2021, 14:3933-3943.
[25]	Daxboeck F, Gattringer R, Mustafa S, et al. Elevated serum alanine aminotransferase (ALT) levels in patients with serologically verified Mycoplasma pneumoniae pneumonia[J]. Clin Microbiol Infect, 2010, 11(6):507-510.
[26]	Xu Q, Zhang L, Hao C, et al. Prediction of bronchial mucus plugs formation in patients with refractory Mycoplasma pneumoniae pneumonia[J]. J Trop Pediatr, 2017, 63(2):148-154.
[27]	Xu X, Li H, Sheng Y, et al. Nomogram for prediction of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia[J]. Sci Rep, 2020, 10(1):4579.
[28]	Smeijsters KMG, Bijkerk RM, Daniels JMA, et al. Effect of bronchoscopy on gas exchange and respiratory mechanics in critically ill patients with atelectasis: an observational cohort study[J]. Front Med, 2018, 5:301.
[29]	Kavaliunaite E, Aurora P. Diagnosing and managing bronchiolitis obliterans in children[J]. Expert Rev Respir Med, 2019, 13(5):481-488.
[30]	Cheng Q, Zhang H, Shang Y, et al. Clinical features and risk factors analysis of bronchitis obliterans due to refractory Mycoplasma pneumoniae pneumonia in children: a nomogram prediction model[J]. BMC Infect Dis, 2021, 21(1):1085.

Options

文章导航

模态框（Modal）标题

摘要

本文引用格式

Abstract

参考文献