目的 总结儿童肉芽肿性口周皮炎的临床特征,并观察克拉霉素的疗效。方法 回顾分析2018年12月至2021年3月克拉霉素治疗儿童肉芽肿性口周皮炎6例的临床资料并复习相关文献。结果 6例患儿中男2例、女4例,中位年龄5.0（4.3~5.0）岁。皮损特点为口周、鼻周的红斑丘疹;6例均累及口周和鼻周,3例同时累及眼周,1例累及颈部,1例累及外阴。中位病程为4.0（3.3~7.8）月。确诊后均给予克拉霉素125 mg,每日1次口服。皮损清除中位时间为18.0（16.0~19.0）周。随访过程中未出现不良反应。结论 克拉霉素在治疗儿童肉芽肿性口周皮炎方面可能有效且安全性良好。

Objectives To summarize the clinical characteristics of granulomatous periorificial dermatitis in children and to observe the efficacy of clarithromycin in the treatment of granulomatous periorificial dermatitis in children.Methods The clinical data of 6 children with granulomatous periorificial dermatitis treated with clarithromycin from December 2018 to March 2021 were retrospectively analyzed and the relevant literature was reviewed.Results Six children (2 boys and 4 girls) with granulomatous periorificial dermatitis were enrolled, and the median age was 5.0 (4.3-5.0) years. The skin lesions were characterized by erythematous papules involving the perioral and perinasal areas in all 6 cases. In addition, 3 cases involved the periocular area, 1 case involved the neck, and 1 case involved the vulva. The median course of the disease was 4.0 (3.3-7.8) months. After diagnosis, 125 mg clarithromycin was given orally, once a day. The median time of skin lesion clearance was 18.0(16.0-19.0) weeks. During the follow-up, no adverse effect was observed. Conclusion Clarithromycin may be effective and safe in the treatment of granulomatous periorificial dermatitis in children.