儿童慢性自发性荨麻疹698例回顾性分析
Retrospective analysis of 698 children with chronic spontaneous urticaria
Received date: 2021-12-23
Online published: 2022-06-07
目的 总结儿童慢性自发性荨麻疹（CSU）的临床特点。方法 回顾性分析2020年1月至2021年6月就诊的CSU患儿的临床资料。结果 共纳入698例CSU患儿,男356例、女342例;中位发病年龄为4.0（2.0~7.0）岁,1~7岁474例（67.9%）,为高发年龄段;中位病程6.0（3.0~12.0）月。119例（17.1%）发病前有感染、食物、疫苗等诱发因素。伴发特应性疾病者最多,共211例（30.2%）。79例患儿进行了抗核抗体（ANA）检查,16例（20.3%）阳性。共84例CSU患儿进行了25-(OH)D检测,中位血清25-(OH)D水平为55.1 nmol/L（26.3~80.6 nmol/L）,对照组为70.2 nmol/L（55.9~93.5 nmol/L）,差异有统计学意义（P<0.01）。结论 儿童CSU有自身的临床特点,存在一定比例ANA阳性以及25-羟维生素D水平较低的现象,值得关注。
林晓 , 郑冰洁 , 陈黎 , 陈茜岚 , 黄迎 , 钱秋芳 . 儿童慢性自发性荨麻疹698例回顾性分析[J]. 临床儿科杂志, 2022 , 40(6) : 461 -464 . DOI: 10.12372/jcp.2022.21e1750
Objective To summarize the clinical characteristics of chronic spontaneous urticaria (CSU) in children. Methods The clinical data of children with CSU from January 2020 to June 2021 were retrospectively analyzed. Results A total of 698 children (356 boys and 342 girls) with CSU were enrolled, and the median age was 4.0 (2.0-7.0) years. The commonest age group was 1-7 years old (474 cases, 67.9%). The median course of disease was 6.0 (3.0-12.0) months. There were predisposing factors such as infection, food and vaccine in 119 children (17.1%) and there were 211 children (30.2%) with atopic diseases. Antinuclear antibody (ANA) test was performed in 79 patients, and 16 patients (20.3%) were positive. A total of 84 children with CSU were tested for 25-(OH) D, and the median level of 25-(OH) D was 55.1 nmol/L (26.3-80.6 nmol/L), compared with 70.2 nmol/L (55.9-93.5 nmol/L) in the control group, the difference between the two groups was statistically significant (P<0.01). Conclusion Chronic spontaneous urticaria in children has its own clinical characteristics. There is a certain proportion of positive antinuclear antibody and 25-hydroxyvitamin D deficiency, which deserves attention.
Key words： chronic spontaneous urticaria; clinical feature; child
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