输血相关性坏死性小肠结肠炎的思考
收稿日期: 2022-03-17
网络出版日期: 2022-08-26
Transfusion-associated necrotizing enterocolitis
Received date: 2022-03-17
Online published: 2022-08-26
雷小平 , 罗丽娟 . 输血相关性坏死性小肠结肠炎的思考[J]. 临床儿科杂志, 2022 , 40(9) : 647 -653 . DOI: 10.12372/jcp.2022.22e0361
Neonatal necrotizing enterocolitis (NEC) is a serious and life-threatening gastrointestinal disease in the neonatal period. The atypical clinical manifestations of NEC, especially in premature infants, are abdominal distension, vomiting, bloody stools and shock. At present, the widely known pathogenesis of NEC includes preterm birth, infection, hypoxia-ischemia and improper feeding, etc. In recent years, the association between red blood cell transfusion (RBCT) and NEC was widely concerned. This article reviewed the relationship between RBCT and NEC, the influence factors, possible pathologic mechanism and the prevention strategies of transfusion-associated necrotizing enterocolitis (TANEC). Based on the available evidences, the author believes that TANEC is a clinical condition. However, anemia is the basis for the onset of TANEC. Prevention of anemia and reasonable blood transfusion are the basic strategies to reduce TANEC.
Key words: necrotizing enterocolitis; red blood cell transfusion; newborn
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