目的 回顾性分析母亲患慢性粒细胞白血病（CML）对新生儿的影响。方法 对2010年1月至2022年1月北京大学人民医院产科收治的41例患CML孕妇及其分娩的36例新生儿和同期年龄匹配的健康孕妇所分娩的36例新生儿进行对照研究,分析母亲患慢性粒细胞白血病对新生儿的影响。结果 母患CML新生儿存活率为100%。与母体健新生儿相比母患CML新生儿早产（22.2%对5.6%）、低出生体重儿发生率（19.4%对0）及需转诊至新生儿科治疗率（30.6%对5.6%）更高（P均<0.05）。母妊娠期暴露于药物与未暴露于药物新生儿相比,先天畸形（4.8%对6.7%）、早产（23.8%对20%）、小于胎龄儿（14.3%对6.7%）和围生期缺氧（28.6%对13.3%）发生率差异均无统计学意义（P均>0.05）。转入新生儿科住院的11例母患CML新生儿平均住院时长为（9.6±4.5）天,其中1例发生血小板减少,无白细胞减少及贫血者;生化检查ALT升高1例,AST增高2例。结论 患CML母亲选择合适的治疗方案,其绝大部分新生儿预后良好。

Objective To retrospectively analyze the influence of chronic myeloid leukemia (CML) on neonates. Methods From January 2010 to January 2022, 41 pregnant women with CML and 36 neonates delivered by them in Peking University People's Hospital were enrolled in this study. Thirty-six neonates born by age-matched healthy pregnant women during the same period were used as controls. The effect of chronic myelogenous leukemia on neonates was analyzed. Results The survival rate of neonates with CML mothers was 100%. Compared with neonates with healthy mothers, the incidence of prematurity (22.2% vs 5.6%, P<0.05), low birth weight (19.4% vs 0, P<0.05) and referral to neonatal ward (30.6% vs 5.6%, P<0.05) was higher in the neonates with CML mothers. Neonates whose mothers were exposed to the drug during pregnancy were compared with neonates whose mothers were not exposed, and there were no differences in the incidence of congenital malformation (4.8% vs 6.7%, P>0.05), prematurity (23.8% vs 20%, P>0.05), small for gestational age (14.3% vs 6.7%, P>0.05) and perinatal asphyxia (28.6% vs 13.3%, P>0.05) between the two groups. The average length of hospital stay was (9.6±4.5) days in 11 neonates with CML mothers who were transferred to neonatal ward. One of them suffered from thrombocytopenia, but none suffered from leukopenia or anemia. Biochemical examination showed abnormal elevation of ALT in 1 child and AST in 2 children. Conclusion When mothers with CML receive appropriate treatment, the vast majority of their newborns have a good prognosis.