儿童气道黏液高分泌研究进展

夏莹 综述; 罗健 审校

doi:10.12372/jcp.2022.21e1630

临床儿科杂志 >

2022 , Vol. 40 >Issue 12: 950 - 955

DOI: https://doi.org/10.12372/jcp.2022.21e1630

文献综述

儿童气道黏液高分泌研究进展

夏莹综述 ,
罗健审校

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重庆医科大学附属儿童医院呼吸科（重庆 400014）

收稿日期: 2021-11-23

网络出版日期: 2022-12-06

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Research progress of airway mucus hypersecretion in children

Ying Reviewer: XIA ,
Jian Reviser: LUO

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Respiratory Department, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China

Received date: 2021-11-23

Online published: 2022-12-06

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摘要

气道黏液是人体呼吸系统防御屏障的重要组成部分，病理状态下，过量的黏液分泌将阻塞气道，引起通气功能障碍，降低黏液纤毛清除功能和局部防御功能。儿童常见气道黏液高分泌疾病与成人有很大不同。对于气道黏液高分泌的评估仍在探索中，其治疗方案以减少黏液产生及促进黏液排出为核心。

关键词： 气道黏液高分泌; 机制; 评估; 儿童

本文引用格式

夏莹综述 , 罗健审校 . 儿童气道黏液高分泌研究进展[J]. 临床儿科杂志, 2022 , 40(12) : 950 -955 . DOI: 10.12372/jcp.2022.21e1630

Abstract

Airway mucus is an important part of the human respiratory system's defense barrier. Under pathological conditions, excessive mucus secretion will block the airway, cause ventilatory dysfunction, and reduce mucociliary clearance and local defense functions. The common airway mucus hypersecretion disease in children is very different from that in adults. The assessment of airway mucus hypersecretion is still under exploration, and the core of its treatment is to reduce mucus production and promote mucus excretion.

Key words： airway mucus hypersecretion; mechanism; assessment; child

参考文献

[1]	黄绍光, 康健, 林江涛, 等. 慢性气道炎症性疾病气道黏液高分泌管理中国专家共识[J]. 中华结核和呼吸杂志, 2015, 38(10): 723-729.
[2]	唐欣, 万南生, 杨夏, 等. 慢性气道黏液高分泌与慢性阻塞性肺疾病的研究进展[J]. 中华结核和呼吸杂志, 2021, 44(6): 574-578.
[3]	鲍一笑, 张平波. 认识和合理处理儿童气道黏液高分泌[J]. 中国实用儿科杂志, 2018, 33(3): 171-174.
[4]	Kesimer M, Ford AA, Ceppe A, et al. Airway mucin concentration as a marker of chronic bronchitis[J]. N Engl J Med, 2017, 377(10): 911-922.
[5]	Hellings PW, Steelant B. Epithelial barriers in allergy and asthma[J]. J Allergy Clin Immunol, 2020, 145(6): 1499-1509.
[6]	Khan MA, Khan ZA, Charles M, et al. Cytokine storm and mucus hypersecretion in COVID-19: review of mechanisms[J]. J Inflamm Res, 2021, 14: 175-189.
[7]	Li J, Ye Z. The potential role and regulatory mechanisms of MUC5AC in chronic obstructive pulmonary disease[J]. Molecules, 2020, 25(19): 4437.
[8]	Choi W, Choe S, Lau GW. Inactivation of FOXA2 by respiratory bacterial pathogens and dysregulation of pulmonary mucus homeostasis[J]. Front Immunol, 2020, 11: 515.
[9]	Rogers DF. Pulmonary mucus: pediatric perspective[J]. Pediatr Pulmonol, 2003, 36(3): 178-88.
[10]	Panchabhai TS, Mukhopadhyay S, Sehgal S, et al. Plugs of the air passages: a clinicopathologic review[J]. Chest, 2016, 150(5): 1141-1157.
[11]	张海邻, 吕芳芳. 儿童气道黏液高分泌疾病[J]. 中国实用儿科杂志, 2018, 33(3): 184-188.
[12]	di Palmo E, Cantarelli E, Catelli A, et al. The predictive role of biomarkers and genetics in childhood asthma exacerbations[J]. Int J Mol Sci, 2021, 22(9): 4651.
[13]	Welsh KG, Rousseau K, Fisher G, et al. MUC5AC and a glycosylated variant of MUC5B alter mucin composition in children with acute asthma[J]. Chest, 2017, 152(4): 771-779.
[14]	田小银, 唐琳, 张祺煜, 等. 儿童慢性化脓性肺疾病临床特征及细菌药敏分析[J]. 临床儿科杂志, 2018, 36(7): 501-504.
[15]	Benscoter DT. Bronchiectasis, chronic suppurative lung disease and protracted bacterial bronchitis[J]. Curr Probl Pediatr Adolesc Health Care, 2018, 48(4): 119-123.
[16]	季新忠, 黄丽, 杜志鹏, 等. 囊性纤维化研究进展[J]. 国际呼吸杂志, 2020, 40(3): 235-237.
[17]	Rafeeq MM, Murad HAS. Cystic fibrosis: current therapeutic targets and future approaches[J]. J Transl Med, 2017, 15(1): 84.
[18]	Tong J, Gu Q. Expression and clinical significance of mucin gene in chronic rhinosinusitis[J]. Curr Allergy Asthma Rep, 2020, 20(11): 63.
[19]	Takeyama K, Shimizu Y, Ishii M, et al. Coexistence of diffuse panbronchiolitis and asthma: reciprocity of neutrophilic and eosinophilic inflammation[J]. Respirol Case Rep, 2017, 5(3): e00232.
[20]	Tracy MC, Okorie CUA, Foley EA, et al. Allergic bronchopulmonary aspergillosis[J]. J Fungi (Basel), 2016, 2(2): 17.
[21]	Monz BU, Sachs P, McDonald J, et al. Responsiveness of the cough and sputum assessment questionnaire in exacerbations of COPD and chronic bronchitis[J]. Respir Med, 2010, 104(4): 534-541.
[22]	American Association for Respiratory Care. AARC Clinical Practice Guidelines. Endotracheal suctioning of mechanically ventilated patients with artificial airways 2010[J]. Respir Care, 2010, 55(6): 758-764.
[23]	Stockley RA, Bayley D, Hill SL, et al. Assessment of airway neutrophils by sputum colour: correlation with airways inflammation[J]. Thorax, 2001, 56(5): 366-372.
[24]	Brody AS, Klein JS, Molina PL, et al. High-resolution computed tomography in young patients with cystic fibrosis: distribution of abnormalities and correlation with pulmonary function tests[J]. J Pediatr, 2004, 145(1): 32-38.
[25]	Dunican EM, Elicker BM, Gierada DS, et al. Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction[J]. J Clin Invest, 2018, 128(3): 997-1009.
[26]	Thompson AB, Huerta G, Robbins RA, et al. The bronchitis index. A semiquantitative visual scale for the assessment of airways inflammation[J]. Chest, 1993, 103(5): 1482-1488.
[27]	Chang AB, Faoagali J, Cox NC, et al. A bronchoscopic scoring system for airway secretions--airway cellularity and microbiological validation[J]. Pediatr Pulmonol, 2006, 41(9): 887-892.
[28]	Eg KP, Thomas RJ, Masters IB, et al. Development and validation of a bronchoscopically defined bronchitis scoring tool in children[J]. Pediatr Pulmonol, 2020, 55(9): 2444-2451.
[29]	Thomas RJ, Eg KP, Masters IB, et al. Towards developing a valid scoring tool for bronchitis during flexible bronchoscopy[J]. Pediatr Pulmonol, 2018, 53(11): 1510-1516.
[30]	姚慧生, 韩晓华. 儿童气道黏液高分泌的管理[J]. 中国实用儿科杂志, 2021, 36(3): 178-184.
[31]	Li X, Jin F, Lee HJ, Lee CJ. Recent advances in the development of novel drug candidates for regulating the secretion of pulmonary mucus[J]. Biomol Ther (Seoul), 2020, 28(4): 293-301.

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