儿童气道黏液高分泌研究进展
Research progress of airway mucus hypersecretion in children
Received date: 2021-11-23
Online published: 2022-12-06
夏莹 综述 , 罗健 审校 . 儿童气道黏液高分泌研究进展[J]. 临床儿科杂志, 2022 , 40(12) : 950 -955 . DOI: 10.12372/jcp.2022.21e1630
Airway mucus is an important part of the human respiratory system's defense barrier. Under pathological conditions, excessive mucus secretion will block the airway, cause ventilatory dysfunction, and reduce mucociliary clearance and local defense functions. The common airway mucus hypersecretion disease in children is very different from that in adults. The assessment of airway mucus hypersecretion is still under exploration, and the core of its treatment is to reduce mucus production and promote mucus excretion.
Key words: airway mucus hypersecretion; mechanism; assessment; child
[1] | 黄绍光, 康健, 林江涛, 等. 慢性气道炎症性疾病气道黏液高分泌管理中国专家共识[J]. 中华结核和呼吸杂志, 2015, 38(10): 723-729. |
[2] | 唐欣, 万南生, 杨夏, 等. 慢性气道黏液高分泌与慢性阻塞性肺疾病的研究进展[J]. 中华结核和呼吸杂志, 2021, 44(6): 574-578. |
[3] | 鲍一笑, 张平波. 认识和合理处理儿童气道黏液高分泌[J]. 中国实用儿科杂志, 2018, 33(3): 171-174. |
[4] | Kesimer M, Ford AA, Ceppe A, et al. Airway mucin concentration as a marker of chronic bronchitis[J]. N Engl J Med, 2017, 377(10): 911-922. |
[5] | Hellings PW, Steelant B. Epithelial barriers in allergy and asthma[J]. J Allergy Clin Immunol, 2020, 145(6): 1499-1509. |
[6] | Khan MA, Khan ZA, Charles M, et al. Cytokine storm and mucus hypersecretion in COVID-19: review of mechanisms[J]. J Inflamm Res, 2021, 14: 175-189. |
[7] | Li J, Ye Z. The potential role and regulatory mechanisms of MUC5AC in chronic obstructive pulmonary disease[J]. Molecules, 2020, 25(19): 4437. |
[8] | Choi W, Choe S, Lau GW. Inactivation of FOXA2 by respiratory bacterial pathogens and dysregulation of pulmonary mucus homeostasis[J]. Front Immunol, 2020, 11: 515. |
[9] | Rogers DF. Pulmonary mucus: pediatric perspective[J]. Pediatr Pulmonol, 2003, 36(3): 178-88. |
[10] | Panchabhai TS, Mukhopadhyay S, Sehgal S, et al. Plugs of the air passages: a clinicopathologic review[J]. Chest, 2016, 150(5): 1141-1157. |
[11] | 张海邻, 吕芳芳. 儿童气道黏液高分泌疾病[J]. 中国实用儿科杂志, 2018, 33(3): 184-188. |
[12] | di Palmo E, Cantarelli E, Catelli A, et al. The predictive role of biomarkers and genetics in childhood asthma exacerbations[J]. Int J Mol Sci, 2021, 22(9): 4651. |
[13] | Welsh KG, Rousseau K, Fisher G, et al. MUC5AC and a glycosylated variant of MUC5B alter mucin composition in children with acute asthma[J]. Chest, 2017, 152(4): 771-779. |
[14] | 田小银, 唐琳, 张祺煜, 等. 儿童慢性化脓性肺疾病临床特征及细菌药敏分析[J]. 临床儿科杂志, 2018, 36(7): 501-504. |
[15] | Benscoter DT. Bronchiectasis, chronic suppurative lung disease and protracted bacterial bronchitis[J]. Curr Probl Pediatr Adolesc Health Care, 2018, 48(4): 119-123. |
[16] | 季新忠, 黄丽, 杜志鹏, 等. 囊性纤维化研究进展[J]. 国际呼吸杂志, 2020, 40(3): 235-237. |
[17] | Rafeeq MM, Murad HAS. Cystic fibrosis: current therapeutic targets and future approaches[J]. J Transl Med, 2017, 15(1): 84. |
[18] | Tong J, Gu Q. Expression and clinical significance of mucin gene in chronic rhinosinusitis[J]. Curr Allergy Asthma Rep, 2020, 20(11): 63. |
[19] | Takeyama K, Shimizu Y, Ishii M, et al. Coexistence of diffuse panbronchiolitis and asthma: reciprocity of neutrophilic and eosinophilic inflammation[J]. Respirol Case Rep, 2017, 5(3): e00232. |
[20] | Tracy MC, Okorie CUA, Foley EA, et al. Allergic bronchopulmonary aspergillosis[J]. J Fungi (Basel), 2016, 2(2): 17. |
[21] | Monz BU, Sachs P, McDonald J, et al. Responsiveness of the cough and sputum assessment questionnaire in exacerbations of COPD and chronic bronchitis[J]. Respir Med, 2010, 104(4): 534-541. |
[22] | American Association for Respiratory Care. AARC Clinical Practice Guidelines. Endotracheal suctioning of mechanically ventilated patients with artificial airways 2010[J]. Respir Care, 2010, 55(6): 758-764. |
[23] | Stockley RA, Bayley D, Hill SL, et al. Assessment of airway neutrophils by sputum colour: correlation with airways inflammation[J]. Thorax, 2001, 56(5): 366-372. |
[24] | Brody AS, Klein JS, Molina PL, et al. High-resolution computed tomography in young patients with cystic fibrosis: distribution of abnormalities and correlation with pulmonary function tests[J]. J Pediatr, 2004, 145(1): 32-38. |
[25] | Dunican EM, Elicker BM, Gierada DS, et al. Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction[J]. J Clin Invest, 2018, 128(3): 997-1009. |
[26] | Thompson AB, Huerta G, Robbins RA, et al. The bronchitis index. A semiquantitative visual scale for the assessment of airways inflammation[J]. Chest, 1993, 103(5): 1482-1488. |
[27] | Chang AB, Faoagali J, Cox NC, et al. A bronchoscopic scoring system for airway secretions--airway cellularity and microbiological validation[J]. Pediatr Pulmonol, 2006, 41(9): 887-892. |
[28] | Eg KP, Thomas RJ, Masters IB, et al. Development and validation of a bronchoscopically defined bronchitis scoring tool in children[J]. Pediatr Pulmonol, 2020, 55(9): 2444-2451. |
[29] | Thomas RJ, Eg KP, Masters IB, et al. Towards developing a valid scoring tool for bronchitis during flexible bronchoscopy[J]. Pediatr Pulmonol, 2018, 53(11): 1510-1516. |
[30] | 姚慧生, 韩晓华. 儿童气道黏液高分泌的管理[J]. 中国实用儿科杂志, 2021, 36(3): 178-184. |
[31] | Li X, Jin F, Lee HJ, Lee CJ. Recent advances in the development of novel drug candidates for regulating the secretion of pulmonary mucus[J]. Biomol Ther (Seoul), 2020, 28(4): 293-301. |
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