新生儿高氨血症的早期诊断及精准干预
Early diagnosis and precise intervention of neonatal hyperammonemia
Received date: 2023-03-03
Online published: 2023-04-07
张拥军 , 朱天闻 . 新生儿高氨血症的早期诊断及精准干预[J]. 临床儿科杂志, 2023 , 41(4) : 241 -246 . DOI: 10.12372/jcp.2023.23e0164
Neonatal hyperammonemia (NHA) is a neonatal critical disease with high neonatal mortality and rapid progression. During the neonatal period, increased blood ammonia can be caused by a variety of genetic and non-genetic disorders with complex causes, such as urea cycle disorders, organic acidemia, fatty acid metabolism disorders, and acquired hyperammonemia due to other serious systemic diseases. The presenting clinical features are not specific. Early detection and identification of etiology and precise intervention through feeding management, amino-reducing drug and hemodialysis can improve the prognosis.
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