单细胞测序技术在川崎病研究中的应用现状
收稿日期: 2023-05-18
网络出版日期: 2023-07-05
基金资助
国家自然科学基金项目(82170518);上海市科委“科技创新行动计划”医学创新研究专项项目(21Y31900304);上海市科委“科技创新行动计划”技术标准项目(21DZ2201400);上海申康医院发展中心2021年临床科技创新项目(SHDC22021305)
Application of single cell sequencing technology in Kawasaki disease research
Received date: 2023-05-18
Online published: 2023-07-05
黄敏 . 单细胞测序技术在川崎病研究中的应用现状[J]. 临床儿科杂志, 2023 , 41(7) : 481 -485 . DOI: 10.12372/jcp.2023.23e0436
Kawasaki disease (KD) is an acute febrile illness which mainly involves the small and medium-sized blood vessels throughout the body, predominantly occurs in children under 5 years old. Coronary artery lesions are its main complication and KD is now the commonest cause of acquired heart disease in children in developed countries. Different from traditional sequencing methods, single-cell sequencing technology can sequence genetic information at single-cell resolution, which can not only solve the problem of cell heterogeneity, but also identify cell subsets, search for biomarkers, and map cell lineages. This commentary will describe the development of single cell sequencing technology and its current application in the field of KD, and provide an outlook on its development.
Key words： single cell sequencing; Kawasaki disease; cell lineage
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