极早发型炎症性肠病发病机制研究进展
Advances in the pathogenesis of very early onset inflammatory bowel disease
Received date: 2022-03-23
Online published: 2023-07-05
庄严 综述 , 黄瑞文 审校 . 极早发型炎症性肠病发病机制研究进展[J]. 临床儿科杂志, 2023 , 41(7) : 549 -555 . DOI: 10.12372/jcp.2023.22e0397
Very early onset inflammatory bowel disease (VEO-IBD) refers to those patients who have developed disease before the age of 6, and their incidence and prevalence have increased rapidly in recent years. With the development of gene sequencing technologies and platforms, the pathogenesis of VEO-IBD has been found to be related to the monogenic variations involved in multiple pathways of immunity. Whether the monogenic variation is the main cause of VEO-IBD is still controversial, but identifying the specific variant type can guide specific treatment to some extent. This paper introduces the possible mechanisms of gene variation and environmental exposure in the pathogenesis of VEO-IBD, focusing on four aspects of monogenic variation associated with VEO-IBD, in order to provide directions for early diagnosis and precise treatment.
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