母乳低聚糖在婴幼儿临床中的应用及在中国的展望
Clinical applications of human milk oligosaccharides in infants
Received date: 2023-05-29
Online published: 2023-07-05
姜璐 , 蔡威 . 母乳低聚糖在婴幼儿临床中的应用及在中国的展望[J]. 临床儿科杂志, 2023 , 41(7) : 556 -560 . DOI: 10.12372/jcp.2023.23e0465
Human milk oligosaccharides (HMOs) are unique and abundant complex carbohydrates in breast milk. As the third most abundant component in breast milk, they have gradually received attention from scholars both domestically and internationally. With the rapid development of analytical techniques and multiomics, the research field of HMOs has made great progress and made great breakthroughs in the past few years. However, we are still in the initial stage of revealing the role and mechanisms of HMOs. However, the conclusions are mainly from foreign clinical studies, and need to be further verified by high-quality randomized clinical trials. In addition, we need to consider its effectiveness in different diseases, environment, and populations. Here, we summarize the roles of HMOs in regulating gut microbiome development, intestinal health, immune system development, and brain development in infants. Additionally, we explore the potential future applications of HMOs in infants in China.
| [1] | Weirich A, Hoffmann GF. Ernst Moro (1874-1951)-a great pediatric career started at the rise of university-based pediatric research but was curtailed in the shadows of Nazi laws[J]. Eur J Pediatr, 2005, 164(10): 599-606. |
| [2] | Petschacher B, Nidetzky B. Biotechnological production of fucosylated human milk oligosaccharides: prokaryotic fucosyltransferases and their use in biocatalytic cascades or whole cell conversion systems[J]. J Biotechnol, 2016, 235: 61-83. |
| [3] | Macfarlane GT, Steed H, Macfarlane S. Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics[J]. J Appl Microbiol, 2008, 104(2): 305-344. |
| [4] | Ward RE, Ni?onuevo M, Mills DA, et al. In vitro fermentability of human milk oligosaccharides by several strains of bifidobacteria[J]. Mol Nutr Food Res, 2007, 51(11): 1398-1405. |
| [5] | Lawson MAE, O'Neill IJ, Kujawska M, et al. Breast milk-derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem[J]. ISME J, 2020, 14(2): 635-648. |
| [6] | Korpela K, Costea P, Coelho LP, et al. Selective maternal seeding and environment shape the human gut microbiome[J]. Genome Res, 2018, 28(4): 561-568. |
| [7] | Garrido D, Ruiz-Moyano S, Kirmiz N, et al. A novel gene cluster allows preferential utilization of fucosylated milk oligosaccharides in Bifidobacterium longum subsp. longum SC596[J]. Sci Rep, 2016, 6: 35045. |
| [8] | Porro M, Kundrotaite E, Mellor DD, et al. A narrative review of the functional components of human breast milk and their potential to modulate the gut microbiome, the consideration of maternal and child characteristics, and confounders of breastfeeding, and their impact on risk of obesity later in life[J]. Nutr Rev, 2023, 81(5): 597-609. |
| [9] | Korpela K, de Vos WM. Early life colonization of the human gut: microbes matter everywhere[J]. Curr Opin Microbiol, 2018, 44: 70-78. |
| [10] | Korpela K, Salonen A, Hickman B, et al. Fucosylated oligosaccharides in mother's milk alleviate the effects of caesarean birth on infant gut microbiota[J]. Sci Rep, 2018, 8(1): 13757. |
| [11] | Borewicz K, Gu F, Saccenti E, et al. Correlating infant fecal microbiota composition and human milk oligosaccharide consumption by microbiota of 1-month-old breastfed infants[J]. Mol Nutr Food Res, 2019, 63(13): e1801214. |
| [12] | Bosheva M, Tokodi I, Krasnow A, et al. Infant formula with a specific blend of five human milk oligosaccharides drives the gut microbiota development and improves gut maturation markers: a randomized controlled trial[J]. Front Nutr, 2022, 9: 920362. |
| [13] | Estorninos E, Lawenko RB, Palestroque E, et al. Term infant formula supplemented with milk-derived oligosaccharides shifts the gut microbiota closer to that of human milk-fed infants and improves intestinal immune defense: a randomized controlled trial[J]. Am J Clin Nutr, 2022, 115(1): 142-153. |
| [14] | Caplan MS. Paediatrics: are human milk oligosaccharides the magic bullet for necrotizing enterocolitis?[J]. Nat Rev Gastroenterol Hepatol, 2017, 14(7): 394-395. |
| [15] | Vandenplas Y, ?o?nowska M, Berni Canani R, et al. Effects of an extensively hydrolyzed formula supplemented with two human milk oligosaccharides on growth, tolerability, safety and infection risk in infants with cow's milk protein allergy: a randomized, multi-center trial[J]. Nutrients, 2022, 14(3): 530. |
| [16] | Eiwegger T, Stahl B, Schmitt J, et al. Human milk--derived oligosaccharides and plant-derived oligosaccharides stimulate cytokine production of cord blood T-cells in vitro[J]. Pediatr Res, 2004, 56(4): 536-540. |
| [17] | Masi AC, Embleton ND, Lamb CA, et al. Human milk oligosaccharide DSLNT and gut microbiome in preterm infants predicts necrotising enterocolitis[J]. Gut, 2021, 70(12): 2273-2282. |
| [18] | Good M, Sodhi CP, Yamaguchi Y, et al. The human milk oligosaccharide 2'-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine[J]. Br J Nutr, 2016, 116(7): 1175-1187. |
| [19] | Xiao L, van De Worp WR, Stassen R, et al. Human milk oligosaccharides promote immune tolerance via direct interactions with human dendritic cells[J]. Eur J Immunol, 2019, 49(7): 1001-1014. |
| [20] | Puccio G, Alliet P, Cajozzo C, et al. Effects of infant formula with human milk oligosaccharides on growth and morbidity: a randomized multicenter trial[J]. J Pediatr Gastroenterol Nutr, 2017, 64(4): 624-631. |
| [21] | Zhang JY, Zhou SM, Wang SH, et al. Risk factors for cow's milk protein allergy in infants: a multicenter survey[J]. Zhongguo Dang Dai Er Ke Za Zhi, 2020, 22(1): 42-46. |
| [22] | Sprenger N, Odenwald H, Kukkonen AK, et al. FUT2-dependent breast milk oligosaccharides and allergy at 2 and 5 years of age in infants with high hereditary allergy risk[J]. Eur J Nutr, 2017, 56(3): 1293-1301. |
| [23] | Gold MS, Quinn PJ, Campbell DE, et al. Effects of an amino acid-based formula supplemented with two human milk oligosaccharides on growth, tolerability, safety, and gut microbiome in infants with cow's milk protein allergy[J]. Nutrients, 2022, 14(11): 2297. |
| [24] | 裴景君. 母乳营养成分与早产儿脑发育的研究进展[J]. 中国当代儿科杂志, 2019, 21(6): 607-612. |
| [25] | Foster JA, Lyte M, Meyer E, et al. Gut microbiota and brain function: an evolving field in neuroscience[J]. Int J Neuropsychopharmacol, 2016, 19(5): pyv114. |
| [26] | Bode L. The functional biology of human milk oligosaccharides[J]. Early Hum Dev, 2015, 91(11): 619-622. |
| [27] | Lin AE, Autran CA, Szyszka A, et al. Human milk oligosaccharides inhibit growth of group B Streptococcus[J]. J Biol Chem, 2017, 292(27): 11243-11249. |
| [28] | Oliveros E, Ramirez M, Vazquez E, et al. Oral supple-mentation of 2'-fucosyllactose during lactation improves memory and learning in rats[J]. J Nutr Biochem, 2016, 31: 20-27. |
| [29] | Berger PK, Plows JF, Jones RB, et al. Human milk oligosaccharide 2'-fucosyllactose links feedings at 1 month to cognitive development at 24 months in infants of normal and overweight mothers[J]. PLoS One, 2020, 15(2): e0228323. |
| [30] | Alderete TL, Autran C, Brekke BE, et al. Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life[J]. Am J Clin Nutr, 2015, 102(6): 1381-1388. |
/
| 〈 |
|
〉 |
沪公网安备 31011002000392号
