儿童常见侵袭性肺部真菌病免疫机制和临床特点
收稿日期: 2023-05-16
网络出版日期: 2023-08-10
基金资助
重庆市首批公共卫生重点学科（专科）
Clinical manifestations and immune mechanism of invasive pulmonary mycosis in children
Received date: 2023-05-16
Online published: 2023-08-10
秦涛 , 许红梅 . 儿童常见侵袭性肺部真菌病免疫机制和临床特点[J]. 临床儿科杂志, 2023 , 41(8) : 566 -570 . DOI: 10.12372/jcp.2023.23e0435
Invasive pulmonary mycosis is a fungal infection of the bronchi and lungs, causing inflammation of the airway mucosa and pulmonary inflammatory granulomas. In severe cases, necrotizing pneumonia may occur, and even hematogenous dissemination to other organs. Its occurrence and development depend on the interaction between external fungal pathogenic factors and the patient's immune function. Children with primary immune dysfunction, hematological malignancies, receiving hematopoietic stem cell transplantation or high-intensity immunosuppressive therapy, long-term invasive catheterization, or severe infections may be susceptible to fungi. This article discusses the immunological pathogenesis and clinical characteristics of invasive pulmonary mycosis in children, hoping to provide theoretical basis for the early detection of the disease.
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