呼吸道微生态的影响因素及其在支气管肺发育不良中的意义
Influencing factors of respiratory tract microecology and its significance in bronchopulmonary dysplasia
Received date: 2022-09-05
Online published: 2023-10-08
任淑英 , 张勤 . 呼吸道微生态的影响因素及其在支气管肺发育不良中的意义[J]. 临床儿科杂志, 2023 , 41(10) : 715 -720 . DOI: 10.12372/jcp.2023.22e1186
Bronchopulmonary dysplasia (BPD) is a common complication in preterm infants with gestational age ≤32 weeks, which has long-term adverse effects on respiratory and nervous system development of newborns. BPD is caused by the combined action of many factors and its etiology is complex. The diversity of respiratory tract microecology and its abnormal evolution mode will increase the risk of BPD. The microecology of the respiratory tract is affected by many factors, and its imbalance can increase the risk of developing various systemic diseases later in life. This paper reviews the influencing factors of respiratory tract microecology and their significance and research progress in BPD, aiming to strengthen the understanding of their relationship and provide a new entry point for the prevention and treatment of BPD.
| [1] | Homan TD, Nayak RP. Short- and long-term complications of bronchopulmonary dysplasia[J]. Respir Care, 2021, 66(10): 1618-1629. |
| [2] | Gilfillan M, Bhandari A, Bhandari V. Diagnosis and management of bronchopulmonary dysplasia[J]. BMJ, 2021, 375: n1974. |
| [3] | Piersigilli F, Van Grambezen B, Hocq C, et al. Nutrients and microbiota in lung diseases of prematurity: the placenta-gut-lung triangle[J]. Nutrients, 2020, 12(2):469. |
| [4] | Gao XY, Dai YH, Fan DZ, et al. The association between the microbes in the tracheobronchial aspirate fluid and bronchopulmonary dysplasia in preterm infants[J]. Pediatr Neonatol, 2020, 61(3): 306-310. |
| [5] | El Saie A, Fu C, Grimm SL, et al. Metabolome and microbiome multi-omics integration from a murine lung inflammation model of bronchopulmonary dysplasia[J]. Pediatr Res, 2022, 92(6):1580-1589. |
| [6] | Lohmann P, Luna RA, Hollister EB, et al. The airway microbiome of intubated premature infants: characteristics and changes that predict the development of bronchopulmonary dysplasia[J]. Pediatr Res, 2014, 76(3): 294-301. |
| [7] | Gallacher D, Mitchell E, Alber D, et al. Dissimilarity of the gut-lung axis and dysbiosis of the lower airways in ventilated preterm infants[J]. Eur Respir J, 2020, 55(5): 1901909. |
| [8] | Pattaroni C, Watzenboeck ML, Schneidegger S, et al. Early-life formation of the microbial and immunological environment of the human airways[J]. Cell Host Microbe, 2018, 24(6):857-865. |
| [9] | Mortensen MS, Rasmussen MA, Stokholm J, et al. Modeling transfer of vaginal microbiota from mother to infant in early life[J]. Elife, 2021, 10: e57051. |
| [10] | Lal CV, Travers C, Aghai ZH, et al. The airway microbiome at birth[J]. Sci Rep, 2016, 6: 31023. |
| [11] | Sakwinska O, Foata F, Berger B, et al. Does the maternal vaginal microbiota play a role in seeding the microbiota of neonatal gut and nose?[J]. Benef Microbes, 2017, 8(5):763-778. |
| [12] | Wu S, Ren L, Li J, et al. Breastfeeding might partially contribute to gut microbiota construction and stabilization of propionate metabolism in cesarean-section infants[J]. Eur J Nutr, 202362(2):615-623. |
| [13] | Kobeshavidze N, Chikviladze D, Gachechiladze K, et al. The microbial structure of the mucous membrane of the respiratory tract in premature infants[J]. Georgian Med News, 2019(288): 131-135. |
| [14] | Sakai AM, Iensue T, Pereira KO, et al. Colonization by multidrug-resistant microorganisms of hospitalized newborns and their mothers in the neonatal unit context[J]. J Infect Dev Ctries, 2020, 14(7): 765-771. |
| [15] | Tirone C, Paladini A, De Maio F, et al. The relationship between maternal and neonatal microbiota in spontaneous preterm birth: a pilot study[J]. Front Pediatr, 2022, 10: 909962. |
| [16] | Hjelms? MH, Shah SA, Thorsen J, et al. Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial[J]. Nat Commun, 2020, 11(1): 426. |
| [17] | Christensen ED, Hjelmso MH, Thorsen J, et al. The developing airway and gut microbiota in early life is influenced by age of older siblings[J]. Microbiome, 2022, 10(1): 106. |
| [18] | Cardelli E, Calvigioni M, Vecchione A, et al. Delivery mode shapes the composition of the lower airways microbiota in newborns[J]. Front Cell Infect Microbiol, 2021, 11: 808390. |
| [19] | Gomez-Gallego C, Garcia-Mantrana I, Salminen S, et al. The human milk microbiome and factors influencing its composition and activity[J]. Semin Fetal Neonatal Med, 2016, 21(6): 400-405. |
| [20] | Chen C, Yin Q, Wu H, et al. Different effects of premature infant formula and breast milk on intestinal microecological development in premature infants[J]. Front Microbiol, 2019, 10: 3020. |
| [21] | Huang J, Zhang L, Tang J, et al. Human milk as a protective factor for bronchopulmonary dysplasia: a systematic review and meta-analysis[J]. Arch Dis Child Fetal Neonatal Ed, 2019, 104(2): F128-F136. |
| [22] | Chen W, Lo YC, Huang PH, et al. Increased antibiotic exposure in early life is associated with adverse outcomes in very low birth weight infants[J]. J Chin Med Assoc, 2022, 85(9): 939-943. |
| [23] | Willis KA, Siefker DT, Aziz MM, et al. Perinatal maternal antibiotic exposure augments lung injury in offspring in experimental bronchopulmonary dysplasia[J]. Am J Physiol Lung Cell Mol Physiol, 2020, 318(2): L407-L418. |
| [24] | Ran X, He Y, Ai Q, et al. Effect of antibiotic-induced intestinal dysbacteriosis on bronchopulmonary dysplasia and related mechanisms[J]. J Transl Med, 2021, 19(1): 155. |
| [25] | Rasmussen MA, Thorsen J, Dominguez-Bello MG, et al. Ecological succession in the vaginal microbiota during pregnancy and birth[J]. ISME J, 2020, 14(9): 2325-2335. |
| [26] | Lehtim?ki J, Thorsen J, Rasmussen MA, et al. Urbanized microbiota in infants, immune constitution, and later risk of atopic diseases[J]. J Allergy Clin Immunol, 2021, 148(1): 234-243. |
| [27] | Schoos AM, Kragh M, Ahrens P, et al. Season of birth impacts the neonatal nasopharyngeal microbiota[J]. Children (Basel), 2020, 7(5): 45. |
| [28] | Rice JL, McGrath-Morrow SA, Collaco JM. Indoor air pollution sources and respiratory symptoms in bronchopulmonary dysplasia[J]. J Pediatr, 2020, 222:85-90. |
| [29] | Brewer MR, Maffei D, Cerise J, et al. Determinants of the lung microbiome in intubated premature infants at risk for bronchopulmonary dysplasia[J]. J Matern Fetal Neonatal Med, 2021, 34(19):3220-3226. |
| [30] | Wang HC, Tsai MH, Chu SM, et al. Clinical characteristics and outcomes of neonates with polymicrobial ventilator-associated pneumonia in the intensive care unit[J]. BMC Infect Dis, 2021, 21(1):965. |
| [31] | Van Mechelen K, Meeus M, Matheeussen V, et al. Association between maternal cervicovaginal swab positivity for Ureaplasma spp. or other microorganisms and neonatal respiratory outcome and mortality[J]. J Perinatol, 2021, 41(6): 1-11. |
| [32] | Polglase GR, Dalton RG, Nitsos I, et al. Pulmonary vascular and alveolar development in preterm lambs chronically colonized with Ureaplasma parvum[J]. Am J Physiol Lung Cell Mol Physiol, 2010, 299(2): L232-L241. |
| [33] | Colaizy TT, Morris CD, Lapidus J, et al. Detection of ureaplasma DNA in endotracheal samples is associated with bronchopulmonary dysplasia after adjustment for multiple risk factors[J]. Pediatr Res, 2007, 61(5 Pt 1):578-583. |
| [34] | Cui TX, Brady AE, Fulton CT, et al. CCR2 mediates chronic LPS-induced pulmonary inflammation and hypoalveolarization in a Murine Model of bronchopulmonary dysplasia[J]. Front Immunol, 2020, 11:579628. |
| [35] | Piersigilli F, Bhandari V. Metabolomics of bron-chopulmonary dysplasia[J]. Clin Chim Acta, 2020, 500: 109-114. |
| [36] | Gentle SJ, Lal CV. Predicting BPD: lessons learned from the airway microbiome of preterm infants[J]. Front Pediatr, 2019, 7: 564. |
| [37] | Xu Y, Huang Y, Shen Z, et al. The nasal microbiome of predicting bronchopulmonary dysplasia in preterm infants[J]. Sci Rep, 2022, 12(1): 7727. |
| [38] | Xu Q, Yu J, Liu D, et al. The airway microbiome and metabolome in preterm infants: potential biomarkers of bronchopulmonary dysplasia[J]. Front Pediatr, 2022, 10: 862157. |
| [39] | Lauer T, Behnke J, Oehmke F, et al. Bacterial colonization within the first six weeks of life and pulmonary outcome in preterm infants <1000 g[J]. J Clin Med, 2020, 9(7):2240. |
| [40] | Qu Y, Guo S, Liu Y, et al. Association between probiotics and bronchopulmonary dysplasia in preterm infants[J]. Sci Rep, 2021, 11(1): 17060. |
| [41] | Chen WY, Lo YC, Huang PH, et al. Increased antibiotic exposure in early life is associated with adverse outcomes in very low birth weight infants[J]. J Chin Med Assoc, 2022, 85(9):939-943. |
| [42] | Li Y, He L, Zhao Q, et al. Microbial and metabolic profiles of bronchopulmonary dysplasia and therapeutic effects of potential probiotics Limosilactobacillus reuteri and Bifidobacterium bifidum[J]. J Appl Microbiol, 2022, 133(2): 908-921. |
| [43] | Freeman AE, Willis KA, Qiao L, et al. Microbial induced redox imbalance in the neonatal lung is ameliorated by live biotherapeutics[J]. Am J Respir Cell Mol Biol, 2023, 68(3):267-268. |
| [44] | Yang K, Dong W. Perspectives on probiotics and bronchopulmonary dysplasia[J]. Front Pediatr, 2020, 8:570247. |
/
| 〈 |
|
〉 |
沪公网安备 31011002000392号
