儿童Peutz-Jeghers综合征内镜下治疗策略
收稿日期: 2023-08-30
网络出版日期: 2023-11-08
基金资助
西安市创新能力强基计划-医学研究项目(22YXYJ0017);西安市儿童医院院级项目-重点项目(2019B01)
Endoscopic treatment of Peutz-Jeghers syndrome in children
Received date: 2023-08-30
Online published: 2023-11-08
Peutz-Jeghers综合征(Peutz-Jeghers syndrome,PJS)在儿童时期的危害主要是息肉相关并发症,消化道反复生长的、多发的、巨大息肉引起肠套叠或肠梗阻,往往需要多次外科开腹手术治疗。随着儿童消化内镜技术的发展,预防性切除胃肠道息肉,极大地降低了PJS患者在儿童时期的开腹率。文章对儿童PJS患者内镜术前诊断、检查时机、术前评估、治疗原则、治疗技巧及术后管理等进行概述,以期为儿童PJS内镜治疗提供参考。
关键词: Peutz-Jeghers综合征; 儿童; 内镜下治疗
杨洪彬 , 方莹 . 儿童Peutz-Jeghers综合征内镜下治疗策略[J]. 临床儿科杂志, 2023 , 41(11) : 808 -810 . DOI: 10.12372/jcp.2023.23e0845
The main hazards of Peutz-Jeghers syndrome in childhood are polyp-related complications. Repeated, multiple, and large polyps in the digestive tract cause intussuscations or intestinal obstruction, which often requires multiple surgical laparotomy. With the development of pediatric digestive endoscopy, prophylactic resection of gastrointestinal polyps has greatly reduced the opening rate of PJS patients in children. This article summarized the preoperative diagnosis, examination timing, preoperative evaluation, treatment principles, surgical techniques and postoperative management of pediatric PJS patients undergoing endoscopy, with a view to providing references for endoscopic treatment of children with PJS.
Key words: Peutz-Jeghers syndrome; child; endoscopic treatment
[1] | 朱全力, 武伟, 陈朋, 等. Peutz-Jeghers综合征的诊治进展[J]. 中国综合临床, 2019, 35(4): 377-380. |
[2] | 张同真, 肖年军, 孙涛, 等. Peutz-Jeghers综合征STK11突变及其与肠套叠累积危险度的关系[J]. 中华消化杂志, 2020, 40(10): 692-696. |
[3] | 赵红梅, 湛美正, 李勇, 等. 多学科联合治疗儿童难治性消化道多发息肉的疗效分析[J]. 临床小儿外科杂志, 2020, 19(4): 326-330. |
[4] | 张同真, 肖年军, 孙涛, 等. 气囊辅助小肠镜治疗Peutz-Jeghers综合征小肠息肉肠套叠的临床探讨[J]. 天津医药, 2020, 48(5): 426-429. |
[5] | Li BR, Sun T, Li J, et al. Primary experience of small bowel polypectomy with balloon-assisted enteroscopy in young pediatric Peutz-Jeghers syndrome patients[J]. Eur J Pediatr, 2020, 179(4): 611-617. |
[6] | Beggs AD, Latchford AR, Vasen HF, et al. Peutz-Jeghers syndrome: a systematic review and recommendations for management[J]. Gut, 2010, 59(7): 975-986. |
[7] | Latchford A, Cohen S, Auth M, et al. Management of Peutz-Jeghers syndrome in children and adolescents: a position paper from the ESPGHAN polyposis working group[J]. J Pediatr Gastroenterol Nutr, 2019, 68(3): 442-452. |
[8] | 赵越, 易飞. Peutz-Jeghers综合征的临床及CT表现[J]. 医学影像学杂志, 2019, 29(1): 108-111. |
[9] | 胡蓉, 王丹. 腹部超声对儿童Peutz-Jeghers综合征及其继发肠套叠的诊断价值[J]. 实用医学影像杂志, 2021, 22(1): 5-7. |
[10] | 中华医学会消化内镜学分会小肠镜和胶囊镜学组, 国家消化系统疾病临床医学研究中心(上海). 中国小肠镜诊治Peutz-Jeghers综合征的专家共识意见(2022年)[J]. 中华消化内镜杂志, 2022, 39(7): 505-515. |
[11] | 杨洪彬, 任晓侠, 葛库库, 等. 胶囊内镜在儿童小肠疾病中的临床应用价值[J]. 中华消化内镜杂志, 2022, 39(12): 978-982 |
[12] | 张同真, 肖年军, 宁守斌. 气囊辅助小肠镜分期治疗波伊茨-耶格综合征小肠息肉165例的安全性和有效性随访研究[J]. 中华消化杂志, 2021, 411(2): 107-111. |
[13] | Cortegoso Valdivia P, Rondonotti E, Pennazio M. Safety and efficacy of an enteroscopy-based approach in reducing the polyp burden in patients with Peutz-Jeghers syndrome: experience from a tertiary referral center[J]. Ther Adv Gastrointest Endosc, 2020, 13: 2631774520919369. |
[14] | Xu ZX, Jiang LX, Chen YR, et al. Clinical features, diagnosis, and treatment of Peutz-Jeghers syndrome: experience with 566 Chinese cases[J]. World J Gastroenterol, 2023, 29(10): 1627-1637. |
[15] | 朱珍妮, 王明芳, 王凤革, 等. 双气囊小肠镜在儿童Peutz-Jeghers综合征引起肠套叠中的初步治疗经验[J]. 中华消化内镜杂志, 2022, 39(4): 322-325. |
[16] | 孙涛, 宁守斌. 《中国小肠镜诊治Peutz-Jeghers综合征的专家共识意见(2022年)》解读[J]. 中华消化内镜杂志, 2022, 39(7): 516-520. |
[17] | 李静, 宁守斌, 李蒙, 等. 预防性应用抗生素在Peutz-Jeghers综合征息肉切除中临床价值的研究[J]. 现代消化及介入诊疗, 2020, 25(5): 652-654. |
/
〈 |
|
〉 |