Presepsin在儿童脓毒症中的研究进展

刘静; 杨新利; 史宝海 综述; 张清秀 审校

doi:10.12372/jcp.2023.22e1144

临床儿科杂志 >

2023 , Vol. 41 >Issue 11: 870 - 874

DOI: https://doi.org/10.12372/jcp.2023.22e1144

文献综述

Presepsin在儿童脓毒症中的研究进展

刘静 ,
杨新利 ,
史宝海综述 ,
张清秀审校

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1.苏州大学附属儿童医院呼吸科（江苏苏州 215003）
2.泰安市中心医院（青岛大学附属泰安市中心医院、泰山医养中心）儿童重症监护室（山东泰安 271000）
3.泰安市中心医院（青岛大学附属泰安市中心医院、泰山医养中心）胸部与食管外科（山东泰安 271000）

收稿日期: 2022-08-22

网络出版日期: 2023-11-08

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Research Progress of Presepsin in Children with Sepsis

Jing Reviewer: LIU ,
Xinli YANG ,
Baohai SHI ,
Qingxiu Reviser: ZHANG

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1. Department of Respiratory Medicine, Children’s Hospital of Soochow Untversity, Suzhou 215003, Jiangsu, China
2. Department of Pediatric Intensive Care Unit, Tai'an City Central Hospital (The Affiliated Tai'an City Central Hospital of Qingdao University, Taishan Medical and Nursing Center), Tai’an 271000, Shandong, China
3. Department of Thoracic Surgery, Tai'an City Central Hospital (The Affiliated Tai'an City Central Hospital of Qingdao University, Taishan Medical and Nursing Center), Tai'an 271000, Shandong, China

Received date: 2022-08-22

Online published: 2023-11-08

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摘要

脓毒症是一种危及生命的疾病，是造成儿科患者发病、乃至死亡的主要原因之一，早期诊断并及时治疗可提高患儿生存率。血培养、C-反应蛋白（CRP）、降钙素原（PCT）、白细胞介素-6（IL-6）等在脓毒症诊断中的应用是目前研究的热点，但其特异度和灵敏度都有局限性，且检测时间过长。可溶性白细胞分化抗原14亚型（sCD14-ST）又称Presepsin，是一种新型生物标志物，它不仅对儿童脓毒症的早期诊断有较高的特异度和灵敏度，对判定脓毒症病情严重程度、抗菌药物治疗效果和预后也有一定的评估价值，且检测方法快捷、准确，具有临床应用的可行性。文章就Presepsin对脓毒症诊断价值评价的研究进行综述，以期开展更多的临床研究指导其应用。

关键词： 可溶性白细胞分化抗原14亚型; 脓毒症; 儿童

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刘静 , 杨新利 , 史宝海综述 , 张清秀审校 . Presepsin在儿童脓毒症中的研究进展[J]. 临床儿科杂志, 2023 , 41(11) : 870 -874 . DOI: 10.12372/jcp.2023.22e1144

Abstract

Sepsis, a life-threatening disease, is one of the main causes of morbidity and even death in pediatric patients. Early diagnosis and timely treatment can improve the patient survival rate. The application of blood culture, C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6) in the diagnosis of sepsis is a hot spot of current research, but its specificity and sensitivity are limited, and the detection time is too long. Soluble leukocyte differentiation antigen 14 subtype (sCD14-ST, or Presepsin) is a novel biomarker that not only has high specificity and sensitivity in the early diagnosis of sepsis in children, but also has certain value in evaluating the severity of sepsis, antimicrobial treatment and prognosis, and the detection method is fast and accurate. It has the feasibility of clinical application.This article reviews the evaluation of Presepsin in the diagnosis of sepsis, with a view to conducting more clinical studies to guide its application.

Key words： soluble leukocyte differentiation antigen 14 subtype; sepsis; child

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