临床报道

儿童急性小脑性共济失调1例报告

  • 张琰 ,
  • 王彩红 ,
  • 王金辉 ,
  • 俞蕙 ,
  • 林彩梅
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  • 1.复旦大学附属儿科医院厦门医院(厦门市儿童医院)神经内科(福建厦门 361006)
    2.复旦大学附属儿科医院厦门医院(厦门市儿童医院)感染科(福建厦门 361006)
    3.复旦大学附属儿科医院厦门医院(厦门市儿童医院)检验科(福建厦门 361006)
    4.国家儿童医学中心 复旦大学附属儿科医院感染科(上海 201102)

收稿日期: 2023-03-28

  网络出版日期: 2024-05-10

基金资助

厦门市医疗卫生指导性项目(3502Z20214ZD1251)

Acute cerebellar ataxia associated with SARS-CoV-2 infection in children: a case report

  • Yan ZHANG ,
  • Caihong WANG ,
  • Jinhui WANG ,
  • Hui YU ,
  • Caimei LIN
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  • 1. Department of Neurology, Children′s Hospital of Fudan University at Xiamen, Xiamen Children′s hospital, Xiamen 361006, Fujian, China
    2. Department of Infectious Diseases, Children′s Hospital of Fudan University at Xiamen, Xiamen Children′s hospital, Xiamen 361006, Fujian, China
    3. Department of Laboratory Medicine, Children′s Hospital of Fudan University at Xiamen, Xiamen Children′s hospital, Xiamen 361006, Fujian, China
    4. Department of Infectious Diseases, Children′s Hospital of Fudan University, National Children′s Medical Center, Shanghai 201102, China

Received date: 2023-03-28

  Online published: 2024-05-10

摘要

回顾性分析1例新型冠状病毒(SARS-CoV-2)感染后急性小脑性共济失调患儿的临床资料和诊治过程,并进行相关文献复习。患儿,女,4岁11个月,因“咳嗽2周,发热3天”入院。入院第2天出现吟诗样语言,独坐不稳,走路不稳。予静脉人免疫球蛋白注射液总量2 g/kg(分4天)及静脉甲基强的松龙2 mg·kg-1·d-1治疗,病情明显好转后予醋酸泼尼松片口服(1 mg·kg-1·d-1)并出院。出院11天电话随访患儿已基本恢复正常,遂停醋酸泼尼松治疗。文献报道3例患儿,均为男性,年龄分别为5岁、13岁、15岁;均为SARS-CoV-2感染后1~2周发病;临床表现均有共济失调步态;2例予静脉甲基强的松龙治疗,1例未予特殊治疗,3例均在2月内恢复正常。SARS-CoV-2 感染所致急性小脑性共济失调一般为感染后1~2周出现,临床多表现为共济失调步态,多为感染后免疫反应所致,预后良好。

本文引用格式

张琰 , 王彩红 , 王金辉 , 俞蕙 , 林彩梅 . 儿童急性小脑性共济失调1例报告[J]. 临床儿科杂志, 2024 , 42(5) : 456 -460 . DOI: 10.12372/jcp.2024.23e0227

Abstract

To investigate the clinical characteristics and treatment of acute cerebellar ataxia in children associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The clinical features, neuroimages, therapy and prognosis of a girl with acute cerebellar ataxia associated with SARS-CoV-2 infection who was hospitalized in Children′s Hospital of Fudan University at Xiamen were retrospectively analyzed and the related literature were summarized. The patient was a girl aged 4 years and 11 months. She was admitted due to cough for 2 weeks and fever for 3 days. On the 3rd day of admission, she was treated by intravenous human immunoglobulin injection with a total amount of 2g/kg (divided into 4 days) and with methylprednisolone 2mg/kg. After significant improvement, she was discharged from hospital with oral prednisone acetate at 1mg/kg/d. At 11 days of follow-up, the girl had returned to normal, and prednisone was stopped. Three articles and 3 children with acute cerebellar ataxia associated with SARS-CoV-2 infection were reported. The age of onset was 5 years old, 13 years old, and 15 years old, respectively. All 3 cases were males, and the onset was 1-2 weeks after SARS-CoV-2 infection. All of them had ataxia gait. Two patients treated with intravenous methylprednisolone, and they were recovered to normal within 2 months. Acute cerebellar ataxia caused by SARS-CoV-2 infection usually appears 1 to 2 weeks after infection, and the clinical manifestations were ataxic gait, which was mostly caused by post-infection immune response, and the prognosis was good.

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