儿童急性小脑性共济失调1例报告
收稿日期: 2023-03-28
网络出版日期: 2024-05-10
基金资助
厦门市医疗卫生指导性项目(3502Z20214ZD1251)
Acute cerebellar ataxia associated with SARS-CoV-2 infection in children: a case report
Received date: 2023-03-28
Online published: 2024-05-10
回顾性分析1例新型冠状病毒(SARS-CoV-2)感染后急性小脑性共济失调患儿的临床资料和诊治过程,并进行相关文献复习。患儿,女,4岁11个月,因“咳嗽2周,发热3天”入院。入院第2天出现吟诗样语言,独坐不稳,走路不稳。予静脉人免疫球蛋白注射液总量2 g/kg(分4天)及静脉甲基强的松龙2 mg·kg-1·d-1治疗,病情明显好转后予醋酸泼尼松片口服(1 mg·kg-1·d-1)并出院。出院11天电话随访患儿已基本恢复正常,遂停醋酸泼尼松治疗。文献报道3例患儿,均为男性,年龄分别为5岁、13岁、15岁;均为SARS-CoV-2感染后1~2周发病;临床表现均有共济失调步态;2例予静脉甲基强的松龙治疗,1例未予特殊治疗,3例均在2月内恢复正常。SARS-CoV-2 感染所致急性小脑性共济失调一般为感染后1~2周出现,临床多表现为共济失调步态,多为感染后免疫反应所致,预后良好。
张琰 , 王彩红 , 王金辉 , 俞蕙 , 林彩梅 . 儿童急性小脑性共济失调1例报告[J]. 临床儿科杂志, 2024 , 42(5) : 456 -460 . DOI: 10.12372/jcp.2024.23e0227
To investigate the clinical characteristics and treatment of acute cerebellar ataxia in children associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The clinical features, neuroimages, therapy and prognosis of a girl with acute cerebellar ataxia associated with SARS-CoV-2 infection who was hospitalized in Children′s Hospital of Fudan University at Xiamen were retrospectively analyzed and the related literature were summarized. The patient was a girl aged 4 years and 11 months. She was admitted due to cough for 2 weeks and fever for 3 days. On the 3rd day of admission, she was treated by intravenous human immunoglobulin injection with a total amount of 2g/kg (divided into 4 days) and with methylprednisolone 2mg/kg. After significant improvement, she was discharged from hospital with oral prednisone acetate at 1mg/kg/d. At 11 days of follow-up, the girl had returned to normal, and prednisone was stopped. Three articles and 3 children with acute cerebellar ataxia associated with SARS-CoV-2 infection were reported. The age of onset was 5 years old, 13 years old, and 15 years old, respectively. All 3 cases were males, and the onset was 1-2 weeks after SARS-CoV-2 infection. All of them had ataxia gait. Two patients treated with intravenous methylprednisolone, and they were recovered to normal within 2 months. Acute cerebellar ataxia caused by SARS-CoV-2 infection usually appears 1 to 2 weeks after infection, and the clinical manifestations were ataxic gait, which was mostly caused by post-infection immune response, and the prognosis was good.
Key words: SARS-CoV-2; acute cerebellar ataxia; child
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