改良CLAG方案治疗儿童复发/难治急性髓系白血病的疗效和安全性
收稿日期: 2023-06-20
网络出版日期: 2024-07-08
基金资助
国家自然科学基金项目(82000151);2018年度北京市临床重点专科项目-儿科(2199000726)
The efficacy and safety of modified CLAG regimen for relapsed or refractory acute myeloid leukemia in children
Received date: 2023-06-20
Online published: 2024-07-08
目的 探讨减低化疗剂量的改良CLAG方案(克拉屈滨、阿糖胞苷、粒细胞集落刺激因子)治疗复发/难治急性髓系白血病(R/R-AML)儿童的疗效及安全性。方法 回顾性分析2016年6月至2023年4月接受改良CLAG方案治疗的R/R-AML患儿的临床资料,计算总体反应率(ORR)、不良反应发生率、总生存(OS)率和无事件生存(EFS)率。结果 26例患儿中复发17例,其中1例为睾丸白血病复发,3例为骨髓2次复发,余均为骨髓首次复发,难治9例。所有患儿均完成1疗程改良CLAG方案化疗,1例未评估治疗反应桥接造血干细胞移植,余25例患儿ORR为84.0 %(21/25)。复发患儿的ORR为81.3 %(13/16),难治患儿的ORR为88.9 %(8/9)。细胞遗传学分层为低危的患儿ORR为76.9 %(10/13),中高危患儿ORR为91.7 %(11/12)。所有患儿64个月的OS率和EFS率分别为69.7 %和63.3 %,15例治疗有反应并顺利桥接异基因造血干细胞移植的患儿64个月OS率和EFS率均为92.3 %。最常见的不良反应为骨髓抑制(100 %)和胃肠道反应(100 %),其次为感染(57.7 %)、转氨酶升高(34.6 %)、出血(19.2 %),1例患儿因4级颅内出血放弃,其他不良反应均经对症治疗后好转。结论 减低化疗剂量的改良CLAG方案是儿童R/R-AML的一种有效、安全的治疗选择。
尚倩雯 , 张永湛 , 陆爱东 , 贾月萍 , 左英熹 , 丁明明 , 张乐萍 , 曾慧敏 . 改良CLAG方案治疗儿童复发/难治急性髓系白血病的疗效和安全性[J]. 临床儿科杂志, 2024 , 42(7) : 589 -594 . DOI: 10.12372/jcp.2024.23e0555
Objective To investigate the efficacy and safety of modified CLAG regimen (cladribine + cytarabine + granulocyte colony-stimulating factor) with reduced chemotherapy dose in the treatment of children with relapsed/refractory acute myeloid leukemia (R/R-AML). Methods The clinical data of children with R/R-AML treated with the modified CLAG regimen from June 2016 to April 2023 were retrospectively analyzed, and the overall response rate (ORR), incidence of adverse reactions, overall survival (OS) rate, and event-free survival (EFS) rate were calculated. Results Among all the children, 17 had recurrent AML, of them 1 had testicular leukemia recurrence, 3 had secondary recurrence in the bone marrow, and the rest had first recurrence in the bone marrow. Nine patients had refractory AML. All children completed 1 course of chemotherapy with modified CLAG regimen, and hematopoietic stem cell transplantation (HSCT) was bridged in 1 patient with no assessed response to treatment, with an ORR of 84.0 % (21/25) in the remaining 25 children. The ORR was 81.3 % (13/16) in the relapsed children and 88.9 % (8/9) in the refractory children. The ORR was 76.9 % (10/13) in children with low risk cytogenetic stratification and 91.7 % (11/12) in children with moderate and high risk cytogenetic stratification. The 64-month OS and EFS rates of all patients were 69.7 % and 63.3 %, respectively. The 64-month OS and EFS rates of 15 children who responded to treatment and successfully bridged allogeneic HSCT were 92.3 %. The most common adverse reactions were myelosuppression (100 %) and gastrointestinal reactions (100 %), followed by infection (57.7 %), elevated transaminases (34.6 %), and bleeding (19.2 %), and one child abandoned treatment due to grade 4 intracranial hemorrhage. All other adverse reactions were improved after symptomatic treatment. Conclusions The modified CLAG regimen with reduced chemotherapy dose is an effective and safe treatment option for children with R/R-AML.
Key words: acute myeloid leukemia; relapsed or refractory; efficacy; safety; child
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