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广州出生队列研究的理念与实践

  • 邱琇 ,
  • 韦冬梅 ,
  • 林珊珊 ,
  • 夏慧敏 ,
  • 周文浩
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  • 1.广州医科大学附属妇女儿童医疗中心 出生队列研究室(广东广州 510623)
    2.广州医科大学附属妇女儿童医疗中心 妇女保健部 广东省高水平临床重点专科(妇幼保健)(广东广州 510623)
    3.广州医科大学附属妇女儿童医疗中心 新生儿外科(广东广州 510623)
    4.广州医科大学附属妇女儿童医疗中心 新生儿科(广东广州 510623)

收稿日期: 2024-08-13

  网络出版日期: 2024-09-04

基金资助

国家自然科学基金面上项目(82173525)

Principles and practice of the Born in Guangzhou Cohort Study

  • Xiu QIU ,
  • Dongmei WEI ,
  • Shanshan LIN ,
  • Huimin XIA ,
  • Wenhao ZHOU
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  • 1. Division of Birth Cohort Study, Guangzhou Medical University, Guangzhou, 510623, China
    2. Department of Women's Health, Guangdong Provincial Key Clinical Specialty of Woman and Child Health, Guangzhou Medical University, Guangzhou, 510623, China
    3. Department of Pediatric Surgery, Guangzhou Medical University, Guangzhou, 510623, China
    4. Division of Neonatology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, China

Received date: 2024-08-13

  Online published: 2024-09-04

摘要

出生队列是探讨生命早期因素对子代生命历程健康的重要研究手段和资源,但目前国内缺少长期随访的大规模出生队列。大型普通人群亲子前瞻性队列——广州出生队列(BIGCS)于2012年正式启动,对参与家庭从孕期到子代开展长期纵向观察。本队列以面对面的随访形式在孕早期、孕中期、孕晚期、分娩时,以及子代出生后6 周、6 个月、1岁、2岁、3岁、6岁、8.5岁等多个时点采集数据信息和生物样本,计划对队列儿童随访至18岁。截至2024年6月,广州出生队列入组超过6.0万名孕妇,儿童5.3万人,6岁儿童人数超过2.7万人,累积生物样本超过290万人份。其主要目标是发现影响妇女和儿童健康的危险因素,探讨其作用机理,验证系列不良妊娠结局和儿童期疾病的病因假设,为改善儿童和妇女健康的策略制定提供科学依据。本文将对广州出生队列的建设概况、研究进展以及未来发展方向做简要介绍。

本文引用格式

邱琇 , 韦冬梅 , 林珊珊 , 夏慧敏 , 周文浩 . 广州出生队列研究的理念与实践[J]. 临床儿科杂志, 2024 , 42(9) : 747 -752 . DOI: 10.12372/jcp.2024.24e0823

Abstract

Birth cohorts are important research tools and resources for exploring the impacts of early life risk factors on offspring’s health throughout their life courses. However, large-scale birth cohorts with long-term follow-up are lack in China. The Born in Guangzhou Cohort Study (BIGCS), a large general-population parent-child prospective cohort, was officially launched in 2012 to conduct long-term longitudinal observation of participating families from pregnancy to offspring. This cohort collected data and biological samples through face-to-face follow-up at multiple time points, including early pregnancy, mid-pregnancy, late pregnancy, delivery, as well as 6 weeks, 6 months, 1 year, 2 years, 3 years, 6 years, and 8.5 years after birth. Cohort children were planned to be followed up to 18 years of age. Up to June 2024, the BIGCS has recruited over 60000 pregnant women and 53000 children, among whom 27000 children are over 6 years old, with over 2.9 million specimens. The aim of this study is to identify the risk factors associated with adverse maternal and children’s health outcomes and explore their potential mechanisms and provide scientific evidences for developing the strategies to improve women and children’s health. This paper will give a brief introduction to the establishment, research progress, and future development of the BIGCS.

参考文献

[1] Barker DJ. The origins of the developmental origins theory[J]. J Intern Med, 2007, 261(5): 412-417.
[2] Chen T, Liu HX, Yan HY, et al. Developmental origins of inflammatory and immune diseases[J]. Mol Hum Reprod, 2016, 22(8): 858-865.
[3] Lawlor DA, Andersen AM, Batty GD. Birth cohort studies: past, present and future[J]. Int J Epidemiol, 2009, 38(4): 897-902.
[4] Sheppard P, Pearce MS, Sear R. How does childhood socioeconomic hardship affect reproductive strategy? Pathways of development[J]. Am J Hum Biol, 2016, 28(3): 356-363.
[5] Niswander KR, Gordon M. The women and their pregnancies: the Collaborative Perinatal Study of the National Institute of Neurological Diseases and Stroke[M]. Bethesda: Washington National Institute of Health, 1972.
[6] Ness AR. The Avon Longitudinal Study of Parents and Children (ALSPAC)--a resource for the study of the environmental determinants of childhood obesity[J]. Eur J Endocrinol, 2004, 151 Suppl 3: U141-U149.
[7] Huang S, Liu S, Huang M, et al. The Born in Guangzhou Cohort Study enables generational genetic discoveries[J]. Nature, 2024, 626(7999): 565-573.
[8] Wang J, Shen S, Price MJ, et al. Glucose, insulin, and lipids in cord blood of neonates and their association with birthweight: differential metabolic risk of large for gestational age and small for gestational age babies[J]. J Pediatr, 2020, 220: 64-72.
[9] Shen S, Lu J, Zhang L, et al. Single fasting plasma glucose versus 75-g oral glucose-tolerance test in prediction of adverse perinatal outcomes: a cohort study[J]. EBioMedicine, 2017, 16: 284-291.
[10] Kuang YS, Lu JH, Li SH, et al. Connections between the human gut microbiome and gestational diabetes mellitus[J]. Gigascience, 2017, 6(8): 1-12.
[11] Liu WY, Lu JH, He JR, et al. Combined effects of air pollutants on gestational diabetes mellitus: a prospective cohort study[J]. Environ Res, 2022, 204(Pt D): 112393.
[12] He JR, Wei DM, Chan FF, et al. Associations between maternal exposure to incense burning and blood pressure during pregnancy[J]. Sci Total Environ, 2018, 610-611:1421-1427.
[13] Huang P, Wei D, Xiao W, et al. Maternal dietary patterns and depressive symptoms during pregnancy: The Born in Guangzhou Cohort Study[J]. Clin Nutr, 2021, 40(5): 3485-3494.
[14] Wei X, He JR, Lin Y, et al. The influence of maternal dietary patterns on gestational weight gain: a large prospective cohort study in China[J]. Nutrition, 2019, 59: 90-95.
[15] Lu MS, Chen QZ, He JR, et al. Maternal dietary patterns and fetal growth: a large prospective cohort study in China[J]. Nutrients, 2016, 8(5): 257.
[16] Lu MS, He JR, Chen Q, et al. Maternal dietary patterns during pregnancy and preterm delivery: a large prospective cohort study in China[J]. Nutr J, 2018, 17(1): 71.
[17] He JR, Yuan MY, Chen NN, et al. Maternal dietary patterns and gestational diabetes mellitus: a large prospective cohort study in China[J]. Br J Nutr, 2015, 113(8): 1292-1300.
[18] He JR, Ramakrishnan R, Wei XL, et al. Fetal growth at different gestational periods and risk of impaired childhood growth, low childhood weight and obesity: a prospective birth cohort study[J]. BJOG, 2021, 128(10): 1615-1624.
[19] Huang JS, Chen QZ, Zheng SY, et al. Associations of longitudinal fetal growth patterns with cardiometabolic factors at birth[J]. Front Endocrinol (Lausanne), 2021, 12: 771193.
[20] Ye QQ, Kong SM, Yin X, et al. Associations of cord blood lipids with childhood adiposity at the age of three years: a prospective birth cohort study[J]. Metabolites, 2022, 12(6): 522.
[21] Wei D, Au Yeung SL, Lu M, et al. Association between prenatal depressive symptoms and eczema in infants: The Born in Guangzhou Cohort Study[J]. Pediatr Allergy Immunol, 2020, 31(6): 662-670.
[22] Wei X, Huang P, Gao C, et al. Associations of maternal weight status with the risk of offspring atopic dermatitis and wheezing by 1 year of age[J]. Pediatr Allergy Immunol, 2022, 33(1): e13703.
[23] Davidson WF, Leung DYM, Beck LA, et al. Report from the National Institute of Allergy and Infectious Diseases workshop on “Atopic dermatitis and the atopic march: mechanisms and interventions”[J]. J Allergy Clin Immunol, 2019, 143(3): 894-913.
[24] Zhou Y, Zhang L, Wang P, et al. Prenatal organophosphate esters exposure and neurodevelopment trajectory in infancy: evidence from the Shanghai Maternal-Child Pairs Cohort[J]. Sci Total Environ, 2024, 927: 172366.
[25] Beaumont RN, Flatley C, Vaudel M, et al. Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth[J]. Nat Genet, 2023, 55(11): 1807-1819.
[26] Zhou B, Yang P, Gong YJ, et al. Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes[J]. Environ Pollut, 2018, 243(Pt B): 1126-1133.
[27] Dai X, Dharmage SC, Abramson MJ, et al. Early life acetaminophen exposure, glutathione S-transferase genes, and development of adolescent asthma in a high-risk birth cohort[J]. J Allergy Clin Immunol, 2020, 146(5): 1035-1044.
[28] Barman M, Nilsson S, Torinsson Naluai ?, et al. Single nucleotide polymorphisms in the FADS gene cluster but not the ELOVL2 gene are associated with serum polyunsaturated fatty acid composition and development of allergy (in a Swedish Birth Cohort)[J]. Nutrients, 2015, 7(12): 10100-10115.
[29] Caporale N, Leemans M, Birgersson L, et al. From cohorts to molecules: adverse impacts of endocrine disrupting mixtures[J]. Science, 2022, 375(6582): eabe8244.
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