论著

儿童哮喘合并阻塞性睡眠呼吸暂停低通气综合征高危人群的临床特点

  • 朱雯靓 ,
  • 谷庆隆 ,
  • 刘传合 ,
  • 沙莉 ,
  • 黄贵民 ,
  • 陆颖霞 ,
  • 赵京 ,
  • 陈育智
展开
  • 1.首都儿科研究所附属儿童医院 变态反应科,(北京 100020)
    2.首都儿科研究所附属儿童医院 耳鼻咽喉头颈外科,(北京 100020)
    3.首都儿科研究所附属儿童医院 儿童健康大数据研究中心(北京 100020)

收稿日期: 2023-11-30

  网络出版日期: 2024-11-08

基金资助

首都儿科研究所青年科研基金项目(QN-2020-04);北京市医院管理中心项目(XTZD20180102);国家自然科学基金资助项目(72004142)

Characteristic of obstructive sleep apnea hypopnea syndrome high risk population in children with bronchial asthma

  • Wenjing ZHU ,
  • Qinglong GU ,
  • Chuanhe LIU ,
  • Li SHA ,
  • Guimin HUANG ,
  • Yingxia LU ,
  • Jing ZHAO ,
  • Yuzhi CHEN
Expand
  • 1. Department of Allergy, Children’s Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China
    2. Department of Otorhinolaryngology, Children’s Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China
    3. Child Health Big Data Research Center, Children’s Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China

Received date: 2023-11-30

  Online published: 2024-11-08

摘要

目的 探讨儿童哮喘合并阻塞性睡眠呼吸暂停低通气综合征(OSAS)高危人群的临床特点。方法 纳入2019年9月至2021年1月就诊的哮喘儿童进行问卷调查。根据问卷结果将哮喘儿童分成两组,分别为OSAS高危组和对照组,分析其临床特征。结果 共纳入哮喘儿童200例,41.00%的哮喘儿童为OSAS高危人群。OSAS高危患儿哮喘未控制率明显增高(60.00%对36.25%,χ2=7.46,P=0.006)。OSAS高危患儿夜间哮喘发作与活动后哮喘发作情况均高于对照组,发生率分别为20.73%对6.78%,26.83%对13.56%(P<0.05);同时OSAS高危患儿腺样体肥大发生率更高(35.37%对8.47%,P<0.05),过敏性鼻炎症状如鼻塞、鼻痒、打喷、流涕评分更高(P<0.05)。结论 哮喘合并OSAS高危患儿更容易出现哮喘控制欠佳、过敏性鼻炎症状重、腺样体肥大发生率高的情况。

本文引用格式

朱雯靓 , 谷庆隆 , 刘传合 , 沙莉 , 黄贵民 , 陆颖霞 , 赵京 , 陈育智 . 儿童哮喘合并阻塞性睡眠呼吸暂停低通气综合征高危人群的临床特点[J]. 临床儿科杂志, 2024 , 42(11) : 922 -926 . DOI: 10.12372/jcp.2024.23e1164

Abstract

Objective This study aimed to explore the clinical characteristics of children with asthma who were at high risk of developing obstructive sleep apnea syndrome (OSAS). Methods A questionnaire survey among outpatient pediatric asthmatic children were conducted from September 2019 to January 2021. Children were categorized into an OSAS high-risk group and a control group based on responses to the questionnaire. Results A total of 200 asthmatic children were included, with 41.00% falling into the OSAS high-risk category. More uncontrolled asthmatic patients were found OSAS high-risk children (60.00% vs. 36.25%, χ2=7.46, P=0.006). Additionally, children in the OSAS high-risk group experienced a higher incidence of nocturnal asthma attacks (20.73% vs. 6.78%, P<0.05) and exercise-induced asthma symptoms (26.83% vs. 13.56%, P<0.05). The prevalence of adenoid hypertrophy was also greater in the OSAS high-risk group (35.37% vs. 8.47%, P<0.05), along with more severe symptoms of allergic rhinitis (P<0.05). Conclusion Children with asthma who are at high risk for OSAS are more likely to exhibit poorly controlled asthma, severe symptoms of allergic rhinitis, and a higher incidence of adenoid hypertrophy.

参考文献

[1] Zhu WJ, Ma HX, Cui HY, et al. Prevalence and treatment of children's asthma in rural areas compared with urban areas in Beijing[J]. Chin Med J (Engl), 2015, 128(17): 2273-2277.
[2] 全国儿科哮喘协作组, 中国疾病预防控制中心环境与健康相关产品安全所. 第三次中国城市儿童哮喘流行病学调查[J]. 中华儿科杂志, 2013, 51(10): 729-735.
[3] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组, 小儿学组, 中华儿科杂志编辑委员会. 儿童变应性鼻炎诊断和治疗指南[J]. 中华耳鼻咽喉头颈外科杂志, 2011, 46(1): 7-8.
[4] 王琴, 傅博建, 杨梅, 等. 儿童哮喘严重程度与体重指数, 脂联素和瘦素的关系[J]. 临床肺科杂志, 2021, 26(1): 50-53.
[5] Chervin RD, Hedger K, Dillon JE, et al. Pediatric sleep questionnaire(PSQ): validity and reliability of scales for sleep disordered breathing, snoring, sleepiness, and behavioral problems[J]. Sleep Med, 2000, 1(1): 21-32.
[6] 李晓丹, 邰隽, 许志飞, 等. 简体中文版儿童睡眠问卷应用于北京地区阻塞性睡眠呼吸暂停综合征儿童筛查的信度和效度评估[J]. 中华耳鼻喉头颈外科杂志, 2016, 51(11): 812-818.
[7] Alanazi TM, Alghamdi HS, Alberreet MS, et al. The prevalence of sleep disturbance among asthmatic patients in a tertiary care center[J]. Sci Rep, 2021, 11(1): 2457.
[8] Lu H, Fu C, Li W, et al. Screening for obstructive sleep apnea syndrome in asthma patients: a prospective study based on Berlin and STOP-Bang questionnaires[J]. J Thorac Dis, 2017, 9(7): 1945-1958.
[9] Wu J, Gu M, Chen S, et al. Factors related to pediatric obstructive sleep apnea-hypopnea syndrome in children with attention deficit hyperactivity disorder in different age groups[J]. Medicine (Baltimore), 2017, 96(42): e8281.
[10] 梁譞, 那飞扬, 秦梦瑶, 等. 儿童支气管哮喘合并阻塞性睡眠呼吸暂停低通气综合征的临床特征及影响因素研究[J]. 中国全科医学, 2023, 26(33): 4225-4230.
[11] Global Initiative for Asthma. GINA Guidelines. Global strategy for asthma management and prevention 2019. [2023-11-30]. https://www.ginasthma.org.
[12] Demoly P, Jankowski R, Chassany O, et al. Validation of a self-questionnaire for assessing the control of allergic rhinitis[J]. Clin Exp Allergy, 2011, 41(6): 860-868.
[13] Schatz M, Meltzer EO, Nathan R, et al. Psychometric validation of the rhinitis control assessment rest: a brief patient-completed instrument for evaluating rhinitis symptom control[J]. Ann Allergy Asthma Immunol, 2010, 104(2): 118-124.
[14] Miedinger D, Neukomm E, Chhajed PN, et al. The use of the asthma control test in general practice and its correlation with asthma control according to the GINA guidelines[J]. Curr Med Res Opin, 2011, 27(12): 2301-2308.
[15] American Thoracic Society. Standards and indications for cardiopulmonary sleep studies in children[J]. Am J Respir Crit Care Med, 1996, 153(2): 866-878.
[16] Li AM, Au CT, So HK, et al. Prevalence and risk factors of habitual snoring in primary school children[J]. Chest, 2010, 138(3): 519-527.
[17] Teodorescu M, Polomis DA, Gangnon RE, et al. Asthma control and its relationship with obstructive sleep apnea (OSA) in older adults[J]. Sleep Disord, 2013: 251567.
[18] Sherbini N, Al-Harbi A, Khan M. Asthma and sleep. In synopsis of sleep medicine[M] Apple Academic Press, Oakville, 2016: 363-377.
[19] Janson C, De Backer W, Gislason T, et al. Increased prevalence of sleep disturbances and daytime sleepiness in subjects with bronchial asthma: a population study of young adults in three European countries[J]. Eur Respir J, 1996, 9(10): 2132-2138.
[20] Walter LM, Tamanyan K, Nisbet L, et al. Pollen levels on the day of polysomnography influence sleep disordered breathing severity in children with allergic rhinitis[J]. Sleep Breath, 2019, 23(2): 651-657.
[21] Marcus CL. Sleep-disordered breathing in children[J]. Am J Respir Crit Care Med, 2001, 164(1): 16-30.
[22] 陆颖霞, 谷庆隆, 庞冲, 等. 治疗阻塞性睡眠呼吸暂停低通气综合征对儿童难治性哮喘的影响[J]. 中华耳鼻喉头颈外科杂志, 2014, 49(6): 462-467.
[23] DelRosso LM. Epidemiology and diagnosis of pediatric obstructive sleep apnea[J]. Curr Probl Pediatr Adolesc Health Care, 2016, 46(1): 2-6.
[24] 中国儿童OSA诊断与治疗指南制订工作组, 中华医学会耳鼻咽喉头颈外科学分会小儿学组, 中华医学会儿科学分会呼吸学组等. 中国儿童阻塞性睡眠呼吸暂停诊断和治疗指南[J]. 中国循证医学杂志, 2020, 20(8): 883-900.
文章导航

/