儿童与成人前庭性偏头痛临床特征的差异性分析
Difference analysis of vestibular migraine clinical features between children and adults
Received date: 2024-09-14
Online published: 2024-12-02
目的 了解儿童前庭性偏头痛(VMC)与成人前庭性偏头痛(VM)患者之间临床特征、听功能及前庭功能检测结果差异,为VMC的诊疗提供参考。方法 回顾性分析2022年1月—2024年7月于眩晕专科门诊就诊,确诊为VMC与VM患者的临床资料,比较两组之间临床特征。结果 共纳入患者186例,其中VMC患者92例,男44例、女48例,中位年龄10.0(6.3~13.0)岁;成人VM患者94例,男23例、女71例,中位年龄52.0(35.0~61.3)岁;VMC患者男性比例高于成人患者,组间差异有统计学意义(P<0.01)。VMC患者中84.8%有明确家族史,81.5%有特殊个人史,均高于成人VM患者(57.4 %和63.8%),组间差异有统计学意义(P<0.01)。VMC患者的纯音听阈异常检出率、摇头性眼震阳性率、温度试验CP值异常率、颈肌前庭诱发肌源性电位以及视频头脉冲试验异常率均低于成人VM患者,组间差异有统计学意义(P<0.05)。结论 VMC患者性别差异不明显,成人VM患者则以女性较多。VMC患者常有特殊个人史及家族史。VMC患者亦可发生听-前庭功能障碍,但程度较成人VM患者轻。
安俊俊 , 刘秀丽 , 田立娟 , 王路阳 , 韩威 . 儿童与成人前庭性偏头痛临床特征的差异性分析[J]. 临床儿科杂志, 2024 , 42(12) : 1006 -1009 . DOI: 10.12372/jcp.2024.24e0986
Objective This study aimed to explore the differences in clinical characteristics, hearing, and vestibular function test results between children with vestibular migraine (VMC) and adults with vestibular migraine (VM), in order to provide a reference for the diagnosis and treatment of VMC. Methods We retrospectively analyzed the clinical data of patients diagnosed with VMC and VM in the vertigo specialist clinic from January 2022 to July 2024 and compared the clinical features between the two groups. Results A total of 186 patients were included, comprising 92 patients with VMC (44 boys and 48 girls) with a median age of 10.0 years (range 6.3 to 13.0 years), and 94 adult patients with VM (23 males and 71 females) with a median age of 52.0 years (range 35.0 to 61.3 years). The proportion of males in the VMC group was significantly higher than that in the adult VM group (P<0.01). A significant majority of VMC patients (84.8%) had a clear family history and 81.5% had a unique personal history, both of which were significantly higher than in adult VM patients (57.4% and 63.8%, P<0.01). The abnormal rates of auditory function, positive rate of head shaking nystagmus, abnormal rate of CP value in the temperature test, and abnormal rates of cervical vestibular evoked myogenic potential and video head impulse test in VMC patients were all lower than those in VM patients, with statistically significant differences between the groups (P<0.05). Conclusions There was no significant gender difference in VMC patients, whereas adult VM patients were predominantly female. VMC patients often have a significant personal and family history. Auditory vestibular dysfunction can also occur in VMC patients, but the severity is less than in adult VM patients.
Key words: vestibular migraine; auditory vestibular function; adult; child
[1] | 李壮壮, 姚青秀, 王会, 等. 儿童眩晕的构成和临床特征[J]. 临床耳鼻咽喉头颈外科杂志, 2019, 33(6): 481-484. |
[2] | Lempert T, Olesen J, Furman J, et al. Vestibular migraine: diagnostic criteria1[J]. J Vestib Res, 2022, 32(1): 1-6. |
[3] | van de Berg R, Widdershoven J, Bisdorff A, et al. Vestibular migraine of childhood and recurrent vertigo of childhood: diagnostic criteria consensus document of the Committee for the Classification of Vestibular Disorders of the Bárány Society and the International Headache Society[J]. J Vestib Res, 2021, 31(1): 1-9. |
[4] | 中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会听力学组. 中国前庭诱发肌源性电位检测临床实践专家共识(2024)[J]. 中华耳鼻咽喉头颈外科杂志, 2024, 59(4): 306-314. |
[5] | 田立娟, 刘秀丽, 尹玉喜, 等. 常见前庭疾病患者水平半规管功能损害的发生状况及评价手段探讨[J]. 临床耳鼻咽喉头颈外科杂志, 2022, 36(9): 670-674. |
[6] | Balzanelli C, Spataro D, Redaelli de Zinis LO. Prevalence of pediatric and adolescent balance disorders: analysis of a monoinstitutional series of 472 patients[J]. Children (Basel), 2021, 8(11): 1056. |
[7] | Nocini R, Baraldi C, Apa E, et al. Visually evoked postural responses (VEPRs) in children with vestibular migraine[J]. Children (Basel), 2021, 9(1): 14. |
[8] | 高帆, 龚树生. 120例眩晕儿童的临床特征分析[J]. 中华内科杂志, 2024, 63(7): 680-685. |
[9] | Marcelli V, Furia T, Marciano E. Vestibular pathways involvement in children with migraine: a neuro-otological study[J]. Headache, 2010, 50(1): 71-76. |
[10] | 刘冰, 李蓓, 张莉, 等. 良性阵发性眩晕与前庭性偏头痛患儿伴焦虑和抑郁情绪的特征分析[J]. 临床耳鼻咽喉头颈外科杂志, 2021, 35(5): 416-419. |
[11] | Orr SL. Headache in children and adolescents[J]. Continuum (Minneap Minn), 2024, 30(2): 438-472. |
[12] | Zhang Q, Du Y, Liu X, et al. Vestibular migraine and recurrent vertigo in children: a diagnostic focus from a tertiary hospital study[J]. Pediatr Neurol, 2024, 158: 86-93. |
[13] | Hwa TP, Patel V, Field E, et al. Asymmetric ocular vestibular evoked myogenic potentials in pediatric vestibular migraine[J]. Otol Neurotol, 2023, 44(6): 578-583. |
[14] | Zhang Q, Wu Q, Chen J, et al. Characteristics of vestibular migraine, probable vestibular migraine, and recurrent vertigo of childhood in caloric and video head impulse tests[J]. Front Neurol, 2022, 13: 1050282. |
[15] | Teggi R, Colombo B, Familiari M, et al. Phenotypes, bedside examination, and video head impulse test in vestibular migraine of childhood compared with probable vestibular migraine and recurrent vertigo in childhood[J]. Front Pediatr, 2023, 11: 1152928. |
[16] | Alnoury MK, Salameh S, Ostrovska A, et al. The first 100 children treated in a newly established pediatric vertigo center[J]. J Otolaryngol Head Neck Surg, 2024, 53: 19160216241265685. |
[17] | Nappi RE, Tiranini L, Sacco S, et al. Role of estrogens in menstrual migraine[J]. Cells, 2022, 11(8): 1355. |
[18] | Raffaelli B, Lange KS. Migraine and pregnancy: gender-specific aspects and current knowledge[J]. Nervenarzt, 2024, 95(4): 308-315. |
[19] | Abouzari M, Cheung D, Pham T, et al. The Relationship between vestibular migraine and motion sickness susceptibility[J]. Otol Neurotol, 2020, 41(8): 1116-1121. |
[20] | Keshavarz B, Golding JF. Motion sickness: current concepts and management[J]. Curr Opin Neurol, 2022, 35(1): 107-112. |
[21] | Saniasiaya J, Salim R. Characteristics and diagnostic approach of vestibular migraine in children and adolescents: a systematic review[J]. Auris Nasus Larynx, 2023, 50(2): 218-227. |
[22] | Guo Z, Wang J, Liu D, et al. Early detection and monitoring of hearing loss in vestibular migraine: extended high-frequency hearing[J]. Front Aging Neurosci, 2023, 14: 1090322. |
[23] | 喻霄, 王路阳, 韩威, 等. 前庭性偏头痛与梅尼埃病双温试验与听力特征的差异性分析[J]. 临床耳鼻咽喉头颈外科杂志, 2019, 33(3): 228-231. |
[24] | Shi S, Wang D, Ren T, et al. Auditory manifestations of vestibular migraine[J]. Front Neurol, 2022, 13: 944001. |
[25] | Curthoys IS, Grant JW, Pastras CJ, et al. A review of mechanical and synaptic processes in otolith transduction of sound and vibration for clinical VEMP testing[J]. J Neurophysiol, 2019, 122(1): 259-276. |
[26] | Curthoys IS, Vulovic V, Burgess AM, et al. Neural basis of new clinical vestibular tests: otolithic neural responses to sound and vibration[J]. Clin Exp Pharmacol Physiol, 2014, 41(5): 371-380. |
[27] | Shen M, Xue S, Wei X, et al. Characteristics of vestibular-evoked myogenic potentials in children with vestibular malformation and severe sensorineural hearing loss[J]. Int J Pediatr Otorhinolaryngol, 2024, 176: 111781. |
[28] | Fuemmeler E, Rodriguez AI, Thomas M, et al. Vestibular evoked myogenic potential (VEMP) test-retest reliability in children[J]. Otol Neurotol, 2020, 41(8): e1052-e1059. |
[29] | Goto F, Wasano K, Kaneda S, et al. Prognostic significance vestibular examination results in patients with vestibular migraine[J]. Front Neurol, 2024, 15: 1370940. |
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