儿童3型腺病毒肺炎预后影响因素分析
收稿日期: 2024-12-31
录用日期: 2025-07-10
网络出版日期: 2025-08-27
基金资助
国家重点研发计划(2021YFC2701800);国家重点研发计划(2021YFC2701801)
Prognostic factors analysis of adenovirus type 3 pneumonia in children
Received date: 2024-12-31
Accepted date: 2025-07-10
Online published: 2025-08-27
目的 分析呼吸道3型腺病毒感染患儿的临床特征以及儿童3型腺病毒肺炎发生的影响因素。方法 回顾性分析2024年1月至10月医院感染科收治的呼吸道3型腺病毒核酸阳性患儿的临床资料。通过多因素logistic回归分析3型腺病毒肺炎发生的可能影响因素。结果 共纳入159例3型腺病毒感染患儿，其中男87例、女72例，中位年龄为59.0（41.0~81.0）个月。多因素logistic回归分析显示扁桃体渗出、C反应蛋白水平升高是儿童3型腺病毒肺炎发生的独立保护因素（P<0.05），而咳嗽、咳痰和D二聚体水平升高是3型腺病毒肺炎发生的独立危险因素（P<0.05）。结论 在儿童呼吸道腺病毒感染的早期，扁桃体渗出可能预示较轻的肺部症状，提示扁桃体在3型腺病毒急性感染发病机制中的重要免疫作用。
项琳娟 , 陈雪欣 , 贾艳会 , 吴宇航 , 丛鑫 , 李伟 , 陈盈盈 , 陈笋 , 黄丽素 . 儿童3型腺病毒肺炎预后影响因素分析[J]. 临床儿科杂志, 2025 , 43(9) : 686 -691 . DOI: 10.12372/jcp.2025.24e1412
Objective To analyze the clinical characteristics of children with respiratory adenovirus type 3 infection and the influencing factors of adenovirus type 3 pneumonia in children. Methods A retrospective analysis was conducted on the clinical data of children with respiratory adenovirus type 3 infection admitted to the hospital's infectious disease department from January to October 2024. The possible influencing factors of the occurrence of adenovirus type 3 pneumonia were analyzed through multivariate logistic regression. Results A total of 159 children (87 boys and 72 girls) with adenovirus type 3 infection were included, with a median age of 59.0 (41.0-81.0) months. Multivariate logistic regression analysis showed that tonsillar exudation and elevated CRP level were independent protective factors for adenovirus type 3 pneumonia in children (P<0.05), while cough, expectoration and elevated D-dimer level were independent risk factors for adenovirus type 3 pneumonia (P<0.05). Conclusions In the early course of respiratory adenovirus type 3 infection in children, tonsillar exudation may indicate mild pulmonary symptoms, suggesting that the tonsils may play an important defensive role in the immune response of acute adenovirus infection.
Key words： adenovirus type 3; pneumonia; tonsillar exudation; child
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