不同听力损失程度婴儿短声与短纯音听性脑干反应波Ⅴ潜伏期-强度函数构建
收稿日期: 2025-07-10
录用日期: 2025-09-01
网络出版日期: 2025-11-28
基金资助
国家自然科学基金面上项目(82271179);国家自然科学基金面上项目(82230035);国家自然科学基金面上项目(82271160);国家重点研发计划(2024YFC2511100);上海交通大学医学院附属新华医院院级临床研究培育基金项目(21XHDB02)
Latency-intensity functions of wave Ⅴ in click and tone-burst auditory brainstem responses in infants with varying degrees of sensorineural hearing loss
Received date: 2025-07-10
Accepted date: 2025-09-01
Online published: 2025-11-28
目的 构建不同听力损失程度感音神经性听力损失(SNHL)婴儿气导短声(click)听性脑干反应(c-ABR)与短纯音ABR(Tb-ABR)波Ⅴ潜伏期-强度函数,为临床ABR阈值判断提供参考。 方法 选取2023年1月至2025年5月在听力障碍及眩晕诊治中心就诊的3~12月龄婴儿作为研究对象,比较听力正常、轻度和中度SNHL三组婴儿在70 dB nHL及阈值强度下click及不同频率Tb-ABR(500、1 000 Hz)波Ⅴ潜伏期,并构建波Ⅴ潜伏期-强度函数。 结果 纳入婴儿120例,男52例、女68例,中位年龄为6(5~9)月龄。所有婴儿按照气导c-ABR阈值分为3组,其中听力正常组90耳、轻度SNHL组90耳、中度SNHL组60耳。70 dB nHL以及阈值强度下,c-ABR、Tb-500 Hz、Tb-1000 Hz ABR潜伏期在三组间的差异均有统计学意义(P<0.01)。70 dB nHL强度下,ABR潜伏期-强度函数模型分别为,c-ABR:Y=0.013X+6.07;Tb-500 Hz:Y=0.032X+9.09;Tb-1000 Hz:Y=0.022X+8.05。阈值强度下,ABR潜伏期-强度函数模型分别为,c-ABR:Y=-0.026X+8.98;Tb-500 Hz:Y=-0.057X+15.59;Tb-1000 Hz:Y=-0.052X+13.22。 结论 c-ABR、Tb-500 Hz、Tb-1000 Hz ABR的波Ⅴ潜伏期与听力损失程度有关。本研究建立的click及不同频率Tb-ABR潜伏期-强度函数模型可为临床阈值判断提供参考。
关键词: 短声ABR; 短纯音ABR; 听力损失; 潜伏期-强度函数模型; 婴儿
沈佳丽 , 马孝宝 , 汪玮 , 王璐 , 楼高忠 , 赵哲弘 , 金玉莲 , 杨军 , 陈建勇 . 不同听力损失程度婴儿短声与短纯音听性脑干反应波Ⅴ潜伏期-强度函数构建[J]. 临床儿科杂志, 2025 , 43(12) : 908 -914 . DOI: 10.12372/jcp.2025.25e0802
Objective To construct the latency-intensity functions of air conduction click auditory brainstem response (c-ABR) and tone-burst ABR (Tb-ABR) waves in infants with varying degrees of sensorineural hearing loss (SNHL), providing a reference for the judgment of clinical ABR thresholds. Methods Infants aged 3 to 12 months who visited the Hearing Impairment and Vertigo Diagnosis and Treatment Center from January 2023 to May 2025 were selected as the research subjects. Wave Ⅴ latencies were compared among the three groups (normal hearing, mild SNHL, and moderate SNHL groups) under both 70 dB nHL and threshold-level intensities using c-ABR and Tb-ABR (500 Hz and 1000 Hz). Latency-intensity function models were then constructed. Results A total of 120 infants were enrolled, including 52 boys and 68 girls, with a median age of 6 (5-9) months. All infants were divided into three groups based on their air-conduction c-ABR thresholds: 90 ears in the normal hearing group, 90 ears in the mild SNHL group, and 60 ears in the moderate SNHL group. At 70 dB nHL and threshold intensity levels, significant differences in wave Ⅴ latencies were found among the three groups for c-ABR, Tb-500 Hz, and Tb-1000 Hz (P<0.01). Latency-intensity function models at 70 dB nHL were as follows, c-ABR: Y=0.013X+6.07; Tb-500 Hz: Y=0.032X+9.09; Tb-1000 Hz: Y=0.022X+8.05. Latency-intensity function models at threshold intensity levels were as follows, c-ABR: Y=-0.026X+8.98; Tb-500 Hz: Y=-0.057X+15.59; Tb-1000 Hz: Y=-0.052X+13.22. Conclusions Wave Ⅴ latencies in c-ABR, Tb-500 Hz, and Tb-1000 Hz are associated with the degree of hearing loss. The latency-intensity function models developed in this study can serve as objective references to aid clinical threshold estimation using ABR.
Key words: click ABR; tone-burst ABR; hearing loss; latency-intensity function model; infant
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