论著

健听婴幼儿骨导短声听性脑干反应波Ⅴ月龄-潜伏期函数模型构建

  • 马孝宝 ,
  • 沈佳丽 ,
  • 汪玮 ,
  • 王璐 ,
  • 楼高忠 ,
  • 赵哲弘 ,
  • 金玉莲 ,
  • 杨军 ,
  • 陈建勇 ,
  • 秦欢
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  • 1.上海交通大学医学院附属新华医院耳鼻咽喉头颈外科 上海交通大学医学院耳科学研究所上海市耳鼻疾病转化医学重点实验室(上海 200092)
    2.杭州市妇幼保健院(杭州市儿童医院)耳鼻咽喉科(浙江杭州 310000)
    3.绍兴市中心医院医共体总院耳鼻咽喉科(浙江绍兴 312030)
* 具有同等贡献
陈建勇,电子信箱:chenjianyong@xinhuamed.com.cn
秦欢, 电子信箱:qinhuan8269@xinhuamed.com.cn

收稿日期: 2025-07-10

  录用日期: 2025-09-01

  网络出版日期: 2025-11-28

基金资助

国家自然科学基金重点项目(82230035);国家自然科学基金面上项目(82271179);国家自然科学基金面上项目(82271160);国家重点研发计划项目(2024YFC251100)

Establishment of an age-latency function model for wave Ⅴ of bone-conduction click-evoked auditory brainstem responses in normal-hearing infants and young children

  • MA Xiaobao ,
  • SHEN Jiali ,
  • WANG Wei ,
  • WANG Lu ,
  • LOU Gaozhong ,
  • ZHAO Zhehong ,
  • JIN Yulian ,
  • YANG Jun ,
  • CHEN Jianyong ,
  • QIN Huan
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  • 1. Department of Otolaryngology, Head and Neck Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Translational Medicine of Ear and Nose Disease, Shanghai 200092, China
    2. Department of Otolaryngology, Hangzhou Maternity and Child Health Care Hospital, Hangzhou Children’s Hospital, Hangzhou 310000, Zhejiang, China
    3. Department of Otolaryngology, Shaoxing Central Hospital, Shaoxing 312030, Zhejiang, China

Received date: 2025-07-10

  Accepted date: 2025-09-01

  Online published: 2025-11-28

摘要

目的 构建健听婴幼儿不同月龄骨导短声听性脑干反应(BC-ABR)波Ⅴ潜伏期函数曲线,为临床BC-ABR阈值的判断提供参考。 方法 选取2019年1月至2022年12月在听力障碍及眩晕诊治中心就诊的听力正常婴幼儿为研究对象。分别选取30 dB nHL及阈值强度2个不同刺激强度进行BC-ABR检测,使用短声(click)记录不同月龄的波Ⅴ潜伏期数值。建立听力正常婴幼儿月龄-潜伏期函数模型,并使用Bland-Altman法行月龄-潜伏期函数模型验证。 结果 研究期间共纳入婴幼儿210名(410耳),男113名(222耳)、女97名(188耳),中位月龄5(3~8)个月,其中0~3月龄组126耳、4~6月龄组168耳、7~12月龄组66耳、13~36月龄组50耳。30 dB nHL和阈值强度下不同月龄组间BC-ABR波Ⅴ潜伏期差异均有统计学意义(P<0.05)。30 dB nHL强度下,月龄-潜伏期函数模型为Y1=7.227+2.563×e-0.1596×xR2=0.44;阈值强度下,月龄-潜伏期函数模型为Y2=8.171+2.739×e-0.1432×xR2=0.33。Bland-Altman法显示30 dB nHL和阈值强度两组实测值与预测值差值落在95%一致性界限之外的比例为3.6%(4/110)和2.7%(3/110)。 结论 BC-ABR的波Ⅴ潜伏期随月龄的增加而逐渐缩短。本研究建立的BC-ABR波Ⅴ月龄-潜伏期函数模型具有一定临床应用价值。

本文引用格式

马孝宝 , 沈佳丽 , 汪玮 , 王璐 , 楼高忠 , 赵哲弘 , 金玉莲 , 杨军 , 陈建勇 , 秦欢 . 健听婴幼儿骨导短声听性脑干反应波Ⅴ月龄-潜伏期函数模型构建[J]. 临床儿科杂志, 2025 , 43(12) : 933 -939 . DOI: 10.12372/jcp.2025.25e0803

Abstract

Objective To construct latency-age function curves of waveⅤin bone-conducted auditory brainstem responses (BC-ABR) across different ages in normal-hearing infants and young children, thereby providing a reference for clinical assessment of BC-ABR thresholds. Methods Infants and young children with normal hearing who visited the Hearing Impairment and Vertigo Diagnosis and Treatment Center from January 2019 to December 2022 were selected as the research subjects. BC-ABRs were recorded at two stimulus intensities (30 dB nHL and threshold level) using click stimuli. The age-latency function model of infants and young children with normal hearing was established, and the Bland-Altman method was used to verify the model. Results A total of 210 infants and young children (410 ears) were included during the study period, including 113 boys (222 ears) and 97 girls (188 ears), with a median age of 5 (3-8) months. Among them, there were 126 ears in the 0-3 months age group, 168 ears in the 4-6 months age group, 66 ears in the 7-12 months age group, and 50 ears in the 13-36 months age group. Significant differences in wave Ⅴ latency were observed among different age groups under both 30 dB nHL and threshold stimulation (P<0.05). The latency-age function model at 30 dB nHL was: Y1=7.227+2.563×e-0.1596×x, with R2=0.44, and at threshold intensity: Y2=8.171+2.739×e-0.1432×x, with R2=0.33, where x is age in months. Bland-Altman analysis showed that the proportions of differences between measured and predicted values falling outside the 95% limits of agreement were 3.6% (4/110) and 2.7% (3/110), respectively. Conclusions Wave Ⅴ latency of BC-ABR shortens progressively with increasing age in infants and young children. The latency-age function models established in this study may serve as useful references for clinical applications.

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