系统性红斑狼疮（SLE）和炎症性肠病（IBD）是两种以异常免疫应答为特征的系统性疾病，发病原因主要由易感基因和环境因素之间的相互作用，在临床中，这两种疾病同时发生比较少见。本例报告中，患儿，女，以腹痛起病入院，经检查诊断为系统性红斑狼疮、溃疡性结肠炎。经英夫利昔单抗（IFX）联合免疫抑制剂治疗，患儿自身免疫症状得到缓解。因此，对患有SLE的患者出现胃肠道症状如腹痛或腹泻时，特别是如果与SLE发作无关，应谨慎排除IBD。

Systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD) are chronic systemic autoimmune conditions marked by aberrant immune activation. The pathogenesis of both diseases is multifactorial, involving a complex interplay between genetic susceptibility and environmental influences. Although the simultaneous presence of SLE and IBD is uncommon in clinical practice, this report describes a pediatric female patient who presented with abdominal pain as the primary manifestation and was ultimately diagnosed with both SLE and ulcerative colitis. Treatment with infliximab (IFX), a tumor necrosis factor-α inhibitor, in combination with immunosuppressive therapy led to significant alleviation of her autoimmune and gastrointestinal symptoms. This case highlights the importance of maintaining a high index of suspicion for underlying IBD when evaluating SLE patients with unexplained gastrointestinal complaints—particularly abdominal pain or diarrhea—that do not correlate with typical disease flares.