论著

65例儿童基孔肯雅热临床分析

  • 龙小慧 ,
  • 廖英蓝 ,
  • 贾金荣
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  • 广州市白云区第二人民医院儿科(广东广州 510000)
龙小慧 电子信箱:13828466792@139.com

收稿日期: 2025-12-25

  录用日期: 2026-03-04

  网络出版日期: 2026-03-31

Clinical study of 65 cases of Chikungunya fever in children

  • LONG Xiaohui ,
  • LIAO Yinglan ,
  • JIA Jinrong
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  • Pediatrics Department, Second People's Hospital of Baiyun District, Guangzhou510000, Guangdong, China

Received date: 2025-12-25

  Accepted date: 2026-03-04

  Online published: 2026-03-31

摘要

目的 通过总结基孔肯雅热在我国部分地区暴发流行中儿童基孔肯雅热患者的临床特点、治疗和预后,旨在提供应对该病的临床经验。方法 选取2025年8月—2025年10月儿科收治的65例基孔肯雅热患儿临床资料进行回顾性分析。结果 儿童基孔肯雅热占同期全院住院基孔肯雅热患者的15.9%(65/408),男女比例1∶0.80,0~3岁8例(12.3%),~6岁11例(16.9%),~11岁36例(55.4%),>11岁10例(15.4%),起病平均年龄(7.9±3.4)岁,均轻症。主要临床表现:发热58例(89.2%),热峰(38.8±0.67)℃,热程(3.5±2.2)天。皮疹59例(90.8%),其中为全身皮疹38例(64.4%),出现皮肤瘙痒35例(59.3%),皮疹(5.5±2.0)天消退。关节痛32例(49.2%),其中疼痛部位主要在踝关节24例(75.0%)和膝关节11例(34.3%),持续时间(3.19±1.65)天,其中2例(6.2%)出现关节肿胀。29例(44.6%)同时存在发热、皮疹、关节痛。其他临床表现包括头痛、头晕、咳嗽、咳痰、咽痛、食欲下降等,并发肺炎1例(1.5%)。所有患儿登革热抗原DEVN-NS1均阴性,小部分患儿有炎症指标升高,2例(3.1%)丙氨酸氨基转移酶升高,19例(29.2%)肌酸激酶同工酶升高。大多数患儿接受对症治疗,药物对症状持续时间无明显影响。全部病例均在隔离期内好转或痊愈出院。结论 大部分的基孔肯雅病毒感染患儿临床症状不典型,重症病例发生率极低。

本文引用格式

龙小慧 , 廖英蓝 , 贾金荣 . 65例儿童基孔肯雅热临床分析[J]. 临床儿科杂志, 2026 , 44(4) : 296 -301 . DOI: 10.12372/jcp.2026.25e1660

Abstract

Objective To summarize the clinical characteristics, treatment, and prognosis of 65 pediatric cases of Chikungunya fever. Methods Clinical data from 65 pediatric patients with Chikungunya fever at the department of pediatrics between August 2025 and October 2025, were retrospectively analyzed. Results Pediatric Chikungunya cases accounted for 15.9% (65/408) of all hospitalized Chikungunya patients during the study period. The male-to-female ratio was 1:0.80. Age distribution: 0-3 years: 8 cases (12.3%); 3-6 years: 11 cases (16.9%); 6-11 years: 36 cases (55.4%); and 10 cases (15.4%) aged >11 years. The mean age at onset was (7.9±3.4) years, with all cases presenting as mild. Fever was present in 58 cases (89.2%), with a fever peak of (38.8±0.67) °C and fever duration of (3.5±2.2) days. Rashes were present in 59 cases (90.8%), including generalized rashes in 38 cases (64.4%). Skin itching occurred in 35 cases (59.3%), with rashes resolving in (5.5±2.0) days. Arthralgia was reported in 32 cases (49.2%), with pain locations including: ankles in 24 cases (75.0%), knees in 11 cases (34.3%), wrists in 7 cases (21.9%), fingers in 7 cases (21.9%), and heels in 1 case (3.1%). The duration of joint pain was (3.19±1.65) days, with joint swelling occurring in 2 cases (6.2%). Twenty-nine cases (44.6%) concurrently presented with fever, rash, and joint pain. Other clinical manifestations included headache, dizziness, cough, producing sputum, sore throat, and decreased appetite, with one case (1.5%) that developed pneumonia. All children tested negative for dengue virus antigen DEVN-NS1, and a few had elevated inflammatory markers; 2 cases (3.1%) had elevated alanine aminotransferase, and 19 cases (29.2%) had elevated creatine kinase isoenzyme. Most children received symptomatic treatment, and the medications didn’t really affect how long the symptoms lasted. All cases improved or were discharged in good condition during the isolation period. Conclusion Most kids with Chikungunya showed unusual clinical symptoms, with very few severe cases.

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