病毒性心肌炎基因易感性研究进展

刘爽; 刘天龙; 刘小雷

doi:10.3969 j.issn.1000-3606.2014.09.023

临床儿科杂志 >

2014 , Vol. 32 >Issue 9: 892

DOI: https://doi.org/10.3969 j.issn.1000-3606.2014.09.023

文献综述

病毒性心肌炎基因易感性研究进展

刘爽 ,
刘天龙 ,
刘小雷

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1. 内蒙古医科大学第二附属医院( 内蒙古呼和浩特　010000)；2. 内蒙古医科大学( 内蒙古呼和浩特　010110)

收稿日期: 2014-09-15

网络出版日期: 2014-09-15

基金资助

国家自然科学基金项目(No.81460066)；内蒙古自治区自然科学基金项目(No.2013MS1201)

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Research advances on gene susceptibility of viral myocarditis

LIU Shuang ,
LIU Tianlong ,
LIU Xiaolei

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1. The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia, China; 2.Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia, China

Received date: 2014-09-15

Online published: 2014-09-15

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摘要

病毒性心肌炎(VMC)是由病毒感染和自身免疫反应共同引起的一种急性或慢性心肌炎性疾病，其最终能够导致扩张性心肌病并伴有危及生命的症状，如心律失常、心力衰竭及突发性心肌梗死等。目前，对于VMC的发病机制尚未完全阐明。据初步研究表明，VMC发病与基因的易感性有关。

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刘爽 , 刘天龙 , 刘小雷 . 病毒性心肌炎基因易感性研究进展[J]. 临床儿科杂志, 2014 , 32(9) : 892 . DOI: 10.3969 j.issn.1000-3606.2014.09.023

Abstract

Viral myocarditis is an acute or chronic inflammatory disease of the myocardium and may progress to dilated cardiomyopathy (DCM) with life-threatening symptoms including heart failure, arrhythmias and sudden cardiac death. At present, the pathogenesis of viral myocarditis still remains unclear, so it is difficult for clinicians to diagnose, treat and find a specific biomarker. However, the pilot researches showed that pathogenesis of viral myocarditis was associated with genetic susceptibility. This article reviewed the above aspects.

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