目的　探讨血清miR-30a 水平与先天性心脏病（CHD）患儿心功能的相关性及其对心力衰竭的诊断价值。 方法　2013 年1 月至2013 年6 月选取CHD 患儿65 例，依据改良Ross 评分法分为心力衰竭组（40 例）和无心力衰竭组（25例）。采用荧光定量PCR 法测定血清miR-30a 水平，超声心动图检测左室射血分数（LVEF）；Spearman 相关分析分析miR-30a 与改良Ross 评分和LVEF 的相关关系，绘制ROC 曲线并计算miR-30a 曲线下面积。 结果　心力衰竭组患儿血清miR-30a 水平较无心力衰竭组显著增高，LVEF 明显降低，差异有统计学意义（P 均<0.001）；血清miR-30a 水平与改良Ross 评分呈正相关（r=0.63，P<0.01），与LVEF 呈负相关（r=–0.32，P<0.01）；miR-30a 诊断心力衰竭的ROC 曲线下面积为0.744。 结论　miR-30a 与CHD 患儿的心功能相关，可作为CHD 合并心力衰竭的检测指标之一。

Objectives To explore the relationship of serum miR-30a and cardiac function in children with congenital heart disease (CHD), and the diagnostic value of serum miR-30a to heart failure. Methods From January 2013 to June 2013, 65 children with CHD were enrolled, and divided into the HF group (patients with heart failure, n=40) and the Non-HF group (patients without heart failure, n=25) according to modified Ross score. The serum miR-30a expression level was quantified by real-time PCR. Left ventricular ejection fraction (LVEF) was tested by echocardiography. The correlation between miR-30a and modified Ross score and LVEF were evaluated with Spearman's analysis. The area under the receiver-operating characteristic (ROC) curve for miR-30a was examined. Results The expression level of miR-30a in HF group was higher than that in Non-HF group, the LVEF was lower in HF group than that in Non-HF group (all P<0.001). The serum miR-30a level was positively correlated with modified Ross score (r=0.63, P<0.01) and negatively correlated with LVEF (r=-0.32, P<0.01). According to ROC analysis, the AUC of miR-30a for detection of HF was 0.7440. Conclusion The expression level of serum miR-30a was closely correlated with the cardiac function, which can be as a biomarker for indicating the heart failure in CHD.