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过敏性紫癜患儿尿肾脏损伤因子-1 水平的变化及意义

  • 茅幼英 ,
  • 周纬 ,
  • 陈同辛 ,
  • 夏慧
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  • 上海交通大学医学院附属上海儿童医学中心( 上海 200127)

收稿日期: 2014-10-15

  网络出版日期: 2014-10-15

The role of urinary kidney injury molecule-1 in pediatric Henoch-Schönlein purpura

  • MAO Youying ,
  • ZHOU Wei ,
  • CHEN Tongxin ,
  • XIA Hui
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  • Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

Received date: 2014-10-15

  Online published: 2014-10-15

摘要

目的 探讨肾脏损伤因子1(KIM-1)与过敏性紫癜(HSP)的关系。方法 采用ELISA法检测48例HSP患儿,其中25例非HSP肾炎患儿(HSP组)、23例HSP肾炎患儿(HSPN组),以及20例健康对照儿童的尿KIM-1水平;并检测尿肌酐、24 h尿蛋白水平,进行分析比较。结果 HSPN组的尿KIM-1/尿肌酐比值较HSP组和对照组增高,差异有统计学意义(P均<0.05);HSP组与对照组的尿KIM-1/尿肌酐比值差异无统计学意义(P>0.05)。HSP患儿的尿KIM-1/尿肌酐比值与24h尿蛋白水平无相关性(r=0.239,P=0.590)。结论 尿KIM-1与HSPN的发生有关,KIM-1表达的上调可能是HSP肾损害发生的重要机制之一。

本文引用格式

茅幼英 , 周纬 , 陈同辛 , 夏慧 . 过敏性紫癜患儿尿肾脏损伤因子-1 水平的变化及意义[J]. 临床儿科杂志, 2014 , 32(10) : 918 . DOI: 10.3969 j.issn.1000-3606.2014.10.005

Abstract

Objective To study the role of urinary kidney injury molecule-1 (KIM-1) in pediatric Henoch-Schönlein purpura (HSP). Methods Urinary levels of KIM-1 were examined using ELISA in 48 children with HSP including 23 HSPN children (HSPN group) and 25 non-HSPN children (HSP group), and 20 healthy children. The levels of urinary creatinine and 24-hour urine protein were also detected. The results were analyzed and compared among groups. Results The ratio of urinary KIM-1/creatinine (Cr) in HSPN children was significantly higher than that in the other two groups (P<0.05). There was no significant difference in the ratio of urinary KIM-1/Cr between HSP group and the control group (P>0.05). The ratio of urinary KIM-1/Cr had no correlation with 24-hour urine protein in all HSP children (r=0.239, P=0.590). Conclusions Urinary KIM-1 may play a role in the pathogenesis of pediatric HSPN.
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