目的　观察硫酸镁对促肾上腺皮质激素(ACTH)治疗婴儿痉挛症(IS)过程中高血压的预防作用。方法　选取2011年5月至2013年10月住院的46例IS患儿，以入住医院分为硫酸镁组23例，给予硫酸镁联合ACTH治疗；对照组23例，单用ACTH治疗，疗程均为2周。观察比较两组高血压的发生率。结果　硫酸镁组患儿没有出现高血压，全部完成疗程；对照组出现6例高血压，18例完成疗程。硫酸镁组在高血压的发生及疗程完成方面均优于对照组，差异有统计学意义(P<0.05)。结论　硫酸镁能预防ACTH在治疗IS过程中高血压的发生，有利于完成疗程，尽早控制病情。

Objective　To examine the preventive effect of magnesium sulfate on hypertension caused by ACTH in the treatment of infantile spasms (IS). Methods 46 children diagnosed as IS were recruited from two hospitals during May, 2011 to October, 2013.23 patients in group A (treatment group) were treated with magnesium sulfate and ACTH in hospital A;another 23 cases in group B (control group) were treated with ACTH only in hospital B. The therapy course was 2 weeks. Results Hypertension was not observed in the treatment group, while 6 children were observed with hypertension in the control group. There was significant difference between the two groups (P<0.05). Conclusions Magnesium sulfate could prevent the incidence of hypertension in the treatment of IS with ACTH, and benefit the completion of treatment course.