目的　探讨儿童Graves病合并系统性红斑狼疮(SLE)的临床特点及诊断。方法　回顾性分析1例Graves病合并SLE患儿的临床资料。结果　13岁女孩，以发热、抽搐为首发症状，经甲状腺功能、头颅磁共振、自身免疫性抗体、肾脏及甲状腺穿刺检查后诊断为SLE合并肾炎、Graves病、脑梗死、脑白质脱髓鞘。结论　长期发热、抽搐患儿除了常见疾病外应考虑到自身免疫性疾病，确诊自身免疫性甲状腺疾病的患儿应查自身抗体排除SLE。

　Objective　To investigate the clinical characteristics, diagnosis and the differential diagnosis of Graves’ disease complicated with systemic lupus erythematosus (SLE) in children. Methods A child diagnosed of Graves’ disease complicated with SLE were reviewed. Results A 13-year-old girl, with fever and convulsions as the onset symptom, had the following examines performed: T3, T4, TSH, brain MRI, TPOAb, TGAb, anti-dsDNA, anti-smDNA, anti-ENA antibodies, antinuclear antibodies, renal and thyroid biopsies. SLE with lupus nephritis, Graves’ disease, cerebral infarction and cerebral white matter demyelination were diagnosed. Conclusions In addition to common diseases, autoimmune disease should also be considered for children with long-time fever and convulsions. Autoantibodies should be checked for children diagnosed of autoimmune thyroid disease.