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尿S-100B 蛋白动态变化对早产儿脑损伤的诊断价值

  • 陆继红 ,
  • 鲍星星 ,
  • 金越 ,
  • 金泉 ,
  • 何珍 ,
  • 肖梅 ,
  • 王奋 ,
  • 汤汉红 ,
  • 张敏
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  • 湖北省武汉市第三医院儿科( 湖北武汉 430074)

收稿日期: 2015-01-15

  网络出版日期: 2015-01-15

Diagnostic value of urine S-100B protein levels in brain injury in premature infants

  • LU Jihong ,
  • BAO Xingxing ,
  • JIN Yue ,
  • JIN Quan ,
  • HE Zhen ,
  • XIAO Mei ,
  • WANG Fen ,
  • TANG Hanhong ,
  • ZHANG Min
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  • Department of Pediatrics, The Third Hospital of Wuhan, Wuhan 430074, Hubei, China

Received date: 2015-01-15

  Online published: 2015-01-15

摘要

 目的 探讨尿S-100B蛋白水平动态变化在早期诊断早产儿脑损伤中的价值。方法 选择2012年1月至12月住院的胎龄<35周的早产儿76例,分别留取生后24、72、120 h尿液,应用化学发光法检测S-100B蛋白含量。根据颅脑超声及磁共振成像(MRI)检查结果,将其分为脑室周围白质软化(PVL)组(16例)、脑室周围及脑室内出血(PVH-IVH)组(20例)及无脑损伤组(40例),比较各组间S-100B的变化。结果 在生后24、72、120 h各时间点,无脑损伤组、PVL组和PVH-IVH组三组间尿S100B蛋白水平差异有统计学意义(P均<0.01);在各时间点,均以无脑损伤组最低,PVL组最高,差异有统计学意义(P均<0.01)。PVL组和PVH-IVH组尿S100B蛋白水平随时间点推移的差异有统计学意义(P均<0.01);均在72 h达到高峰,120 h时有所下降。结论 尿S100-B蛋白水平可作为早期预测脑损伤的敏感标志物,动态监测有助于判断疾病严重程度及评估患儿预后。

本文引用格式

陆继红 , 鲍星星 , 金越 , 金泉 , 何珍 , 肖梅 , 王奋 , 汤汉红 , 张敏 . 尿S-100B 蛋白动态变化对早产儿脑损伤的诊断价值[J]. 临床儿科杂志, 2015 , 33(1) : 44 . DOI: 10.3969 j.issn.1000-3606.2015.01.011

Abstract

 Objective To investigate the diagnostic value of urine S-100B protein levels in brain injury in premature infants. Methods A total of 76 premature infants with gestational age less than 35 weeks were selected from January to December 2012. Urine samples were obtained at 24 h, 72 h and 120 h after birth, and S-100B protein levels in urine were detected by chemiluminescence. According to the results of cranial ultrasound and MRI, all infants were divided into periventricular leukomalacia (PVL) group (n=16), periventricular-intraventricular haemorrhage (PVH-IVH) group (n=20) and no brain injury group (control group) (n=40). Urine S-100B protein levels were compared among groups. Results There was significant difference in Urine S-100B protein levels among PVL, PVH-IVH and control groups at 24 h, 72 h and 120 h after birth (P<0.01). At each time point, the urine S-100B protein levels were highest in PVL group and lowest in control group, and the differences were significant (P<0.01). The urine S-100B protein levels were significantly different among different time points in PVL and PVH-IVH groups (P<0.01), reaching a peak at 72 h and starting to decrease at 120 h. Conclusions Urine S-100B protein can be used as a sensitive indicator of brain injury in judging disease severity and assessing prognosis.
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