转录因子GATA6 在心脏发育以及先天性房间隔缺损中的作用研究进展

许细财; 李奋; 周万平; 朱荻琦; 吉炜; 胡晶晶; 陈轶维; 钱咿娇; 戴柯

doi:10.3969 j.issn.1000-3606.2015.04.022

临床儿科杂志 >

2015 , Vol. 33 >Issue 4: 380

DOI: https://doi.org/10.3969 j.issn.1000-3606.2015.04.022

文献综述

转录因子GATA6 在心脏发育以及先天性房间隔缺损中的作用研究进展

许细财 ,
李奋 ,
周万平 ,
朱荻琦 ,
吉炜 ,
胡晶晶 ,
陈轶维 ,
钱咿娇 ,
戴柯

展开

上海交通大学医学院附属上海儿童医学中心心内科( 上海　200127)

收稿日期: 2015-04-15

网络出版日期: 2015-04-15

收起

The research progress of GATA6 in heart development and isolated atrial septal defect

XU Xicai ,
LI Fen ,
ZHOU Wanping ,
ZHU Diqi ,
JI Wei ,
HU Jingjing ,
CHEN Yiwei ,
QIAN Yijiao ,
DAI Ke

Expand

Department of Pediatric Cardiology, Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

Received date: 2015-04-15

Online published: 2015-04-15

Fold

摘要

转录因子GATA6属于GATA转录因子家族，具有2个保守的锌指结构域。它不仅存在于胚胎组织，并且对心脏、肺和胰腺中细胞功能的维持起重要作用。该文对转录因子GATA6在心脏发育以及先天性房间隔缺损中的作用作一综述，探讨其对人类房间隔缺损疾病诊断和治疗的价值。

本文引用格式

许细财 , 李奋 , 周万平 , 朱荻琦 , 吉炜 , 胡晶晶 , 陈轶维 , 钱咿娇 , 戴柯 . 转录因子GATA6 在心脏发育以及先天性房间隔缺损中的作用研究进展[J]. 临床儿科杂志, 2015 , 33(4) : 380 . DOI: 10.3969 j.issn.1000-3606.2015.04.022

Abstract

GATA6 transcription factor belongs to the GATA family and contains 2 conserved zinc finger DNA binding domains. GATA6 not only presents in embryonic tissues but also found in heart, lung and pancreas and is essential for the maintenance of their function.The present review focuses on the critical roles of GATA6 in heart development and atrial septal defect to provide theoretical basis for diagnosis and treatment of atrial septal defect.

Options

文章导航

模态框（Modal）标题

摘要

本文引用格式

Abstract