实验研究

Notch1 的异常激活与T 细胞型急性淋巴细胞白血病

  • 闫慧 ,
  • 莫茜 ,
  • 刘兰波
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  • 上海交通大学医学院附属上海儿童医学中心( 上海 200127)

收稿日期: 2015-05-15

  网络出版日期: 2015-05-15

Abnormal activation of Notch1 and T-cell acute lymphoblastic leukemia

  • YAN Hui ,
  • MO Xi ,
  • LIU Lanbo
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  • Pediatric Institute of Translational Medicine, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127,China)

Received date: 2015-05-15

  Online published: 2015-05-15

摘要

 Notch1受体的异常激活在T细胞型急性淋巴细胞白血病(T-ALL)的发病中起主导作用。近期研究表明,超过60%的T-ALL患者中存在Notch1的激活性突变。文章简要介绍Notch1异常激活在T-ALL发病中的作用,以及针对Notch1异常激活的现有方法及其面临的问题,为T-ALL的研究及靶向治疗提供参考。

本文引用格式

闫慧 , 莫茜 , 刘兰波 . Notch1 的异常激活与T 细胞型急性淋巴细胞白血病[J]. 临床儿科杂志, 2015 , 33(5) : 483 . DOI: 10.3969 j.issn.1000-3606.2015.05.021

Abstract

Abnormal activation of Notch1 plays pivotal roles in the molecular pathogenesis of human T-cell acute lymphoblastic leukemia (T-ALL). Activating Notch1 mutations present in over 60% of the T-ALL patients. However, so far, there is no therapy with little side effects that specifically targets the abnormally activated Notch1 pathway-induced T-ALL. The present study briefly reviewed the effects of abnormal activation of Notch1 in the pathogenesis of T-ALL, as well as the current approaches targeting Notch1 and its limitations, thus providing some guidance for the research and development of clinical therapies targeting T-ALL.
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