目的　探讨新生儿坏死性小肠结肠炎(NEC)的研究趋势。方法　利用共词分析法，在PubMed中检索关于NEC的论著，将符合纳入标准的文献导入书目共现分析系统(BICOMB)，通过BICOMB系统确定主题词的词频，生成高频主题词的词篇矩阵。将高频主题词的词篇矩阵导入SPSS软件进行系统聚类法以得到主题词聚类树图。最终对比不同时间区间的高频词和主题词聚类树图。结果　通过PubMed数据库进行检索后，共命中符合纳入标准的文献1 479篇。对比分析2008年以前和2009至2014年之间的高频主题词和共词聚类分析结果后发现，2个研究时间区间大部分的研究热点相同，但2008年以后部分研究热点消失并且出现新的热点。结论　共词分析法能够实现对NEC相关研究的变化趋势的把握。

Objective　To explore the research trends of neonatal necrotizing enterocolitis (NEC) using a co-word analysis. Methods Original articles about NEC were searched throughout the PubMed Database using a co-word analysis. The included articles were analyzed by Bibliographic Items Co-occurrence Matrix Builder (BICOMB) to retrieve MeSH words with high frequency. Then SPSS software was used to perform co-word cluster analysis and results of cluster analysis were compared between before 2008 and after 2008. Results　In total, 1479 articles were included into the co-word analysis with 776 dated before 2008 and 703 dated from 2009 to 2014. By comparison of MeSH words with high frequency between before 2008 and 2009-2014 and after co-word cluster analysis, it was found that most research hotspots were same in two periods. However, after 2008, some research hotspots disappeared and a few new hotspots were emerged. Conclusions Co-word analysis is helpful to master the research trends of NEC.