随着抗生素不合理使用的增多，细菌耐药的形势越来越严峻，多重耐药(MDR)细菌的报道屡见不鲜，给临床感染治疗带来了极大的困难。为了治疗MDR细菌引起的感染以及减少耐药菌的产生，研究人员正积极研究非抗生素物质的抗菌治疗策略。文章综述其中已证实具有疗效的噬菌体、金属及金属螯合剂、免疫疗法、光动力疗法、一氧化氮、小分子化学抑制剂、生物肽、中药等的研究现状。

With the inappropriate use of antibiotics, the situation of bacterial resistance is more and more severe. The emergence of multidrug-resistant (MDR) bacteria has made it difficult to cure the infections in clinical. For treatment the infections caused by MDR and reducucton of the generation of resistant bacteria, researchers are actively studying on the nonantibiotic substances for antibacterial activity. In this paper, the advances in those with confirmed effects such as phage therapy, metal/chelation therapy, immunization therapy, photodynamic therapy, and nitric oxide (NO)-based therapies, small molecule inhibitors, antimicrobial peptides and Chinese herb were reviewed.