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N 末端B 型钠尿肽原和肌酸激酶同工酶MB 对肺炎患儿心力衰竭的诊断价值

  • 贾秀红 ,
  • 唐慎华 ,
  • 张燕燕 ,
  • 李建厂 ,
  • 李晓梅
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  • 滨州医学院附属医院儿科( 山东滨州 256603)

收稿日期: 2015-08-15

  网络出版日期: 2015-08-15

Diagnostic value of N-terminal pro-brain natriuretic peptide and MB isoenzyme of creatine kinase for heart failure in pneumonia children 

  • JIA Xiuhong ,
  • TANG Shenhua ,
  • ZHANG Yanyan ,
  • LI Jianchang ,
  • LI Xiaomei
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  • Department of Pediatrics, Binzhou Medical University Hospital, Binzhou 256603, Shandong, China

Received date: 2015-08-15

  Online published: 2015-08-15

摘要

目的 评价N末端B型钠尿肽原(NT-proBNP)和肌酸激酶同工酶MB(CK-MB)诊断肺炎患儿心力衰竭的价值。方法 检测132例肺炎合并心力衰竭、138例肺炎未合并心力衰竭患儿和61例健康儿童的血清NT-proBNP和CK-MB水平。以受试者工作特征(ROC)曲线分析法和logistic回归分析评价NT-proBNP和CK-MB对诊断肺炎患儿心力衰竭的价值。结果 三组间血清NT-proBNP和CK-MB水平差异有统计学意义(P<0.01);肺炎合并心力衰竭患儿最高,其次为肺炎未合并心力衰竭患儿,三组间两两比较差异均有统计学意义(P均<0.01)。血清NT-proBNP和CK-MB在肺炎患儿中诊断心力衰竭的曲线下面积分别为0.85和0.72,两者联合诊断的曲线下面积为0.87。结论 在肺炎患儿中,血清NT-proBNP和CK-MB可以作为辅助诊断心力衰竭的指标。

本文引用格式

贾秀红 , 唐慎华 , 张燕燕 , 李建厂 , 李晓梅 . N 末端B 型钠尿肽原和肌酸激酶同工酶MB 对肺炎患儿心力衰竭的诊断价值[J]. 临床儿科杂志, 2015 , 33(8) : 694 . DOI: 10.3969 j.issn.1000-3606.2015.08.004

Abstract

 Objective To investigate the diagnostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) and MB isoenzyme of creatine kinase (CK-MB) for heart failure (HF) in pneumonia children. Methods The NT-proBNP and CKMB were assayed in 132 pneumonia children with HF, 138 pneumonia children without HF and 62 healthy children were recruited into this study. A receiver operating characteristics (ROC) curve and a logistic regression model were employed to assess the diagnostic accuracy of NT-proBNP and CK-MB for HF in pneumonia children. Results Pneumonia children with HF had higher blood NT-proBNP and CK-MB than those in pneumonia children without HF and healthy controls (P<0.01 for both). Pneumonia children with HF had higher blood NT-proBNP and CK-MB than the pneumonia children without HF. The area under curves (AUCs) of NT-proBNP and CK-MB for HF were 0.85 and 0.72, respectively. The AUC for their combinational usage was 0.87. Conclusion Both NT-proBNP and CK-MB are effective markers as diagnostic adjuncts for HF in pneumonia children. Combination of NT-proBNP and CK-MB can improve the diagnostic accuracy for HF in pneumonia children.
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