目的　探讨新生儿起病的克隆恩病的诊断和治疗。方法　回顾性分析1例新生儿起病的克隆恩病患儿的临床资料。结果　男性患儿，生后5 d即出现间断发热、口腔溃疡、皮肤脓疱疹、间断腹泻伴白细胞增高，先后诊断为“脓毒血症、细菌性肠炎、白塞病、免疫缺陷病、营养性贫血、牛奶不耐受、炎症性肠病”，直肠黏膜病理诊断及术后肠管病理检查确诊为克隆恩病，于8月龄死于肠穿孔。结论　对于新生儿起反复口腔溃疡、皮肤脓疱疹、肛周溃疡和发热的患儿，应及早进行结肠镜检查以明确诊断。

Objective　To investigate the diagnosis and treatment of Crohn disease in neonates. Methods　 The clinical data of one case of neonatal onset Crohn disease were retrospectively analyzed. Results　 Male infant had intermittent fever, recurrent oral ulcers, skin impetigo and intermittent diarrhea with increased WBC counts from five days after birth. He had been diagnosed as sepsis, bacterial enteritis, Behcet's disease, immunodeficiency disease, nutritional anemia, milk intolerance, and inflammatory bowel disease. Finally he was diagnosed as Crohn disease by rectal mucosa pathology and postoperative bowel pathology. He died of intestinal perforation on 8 months. Conclusions 　The infants who have recurrent oral ulcers, skin impetigo, perianal ulcers and fever from neonatal should undergo colonoscopy for the diagnosis.