目的 分析轻度胃肠炎伴婴幼儿良性惊厥(BICE)复发以及转化为癫痫的可能危险因素。方法 将264例BICE患儿按惊厥发生次数分为单次组134例(惊厥1次),多发组130例(惊厥次数≥2次);按惊厥持续时间分为,短时组186例(惊厥持续时间<5 min),长时组78例(惊厥时间≥5 min),分析其住院及随访资料。结果 多发组有9.23%复发,6.15%转化为癫痫;单次组有2.99%复发,0.75%转化为癫痫,两组间复发及转化为癫痫比例的差异均有统计学意义(P均<0.05)。长时组有12.82%复发,8.97%转化为癫痫;短时组有3.23%复发,1.08%转化为癫痫,两组间复发及转化为癫痫比例的差异均有统计学意义(P均<0.01)。结论 BICE患儿有复发以及转化为癫痫的可能,惊厥次数≥2次,惊厥持续时间≥5 min是BICE患儿复发以及转化为癫痫的可能危险因素。
Objective To analyze the potential risk factors for relapse and development of epilepsy in patients with benign infantile convulsions associated with mild gastroenteritis (BICE). Methods A total of 264 cases of BICE were recruited. According to the frequency of convulsions, the patients were divided into single group (n=134, convulsion once), and multiple group (n=130, convulsions ≥ 2 times). According to convulsion duration, the patients were divided into short-term group (n=186, convulsions duration <5 minutes) , and long-term group (n=78, convulsion duration ≥ 5 minutes). The clinical data obtained during hospitalization and follow-up were analyzed. Results In multiple group, 9.23% were relapsed and 6.15% developed epilepsy. In single group, 2.99% were relapsed and 0.75% developed epilepsy. There were significantly different in the rate of relapses and development of epilepsy between two groups (P<0.05). In the long-term group, 12.82% were relapsed and 8.97% developed epilepsy. In the short-term group, 3.23% were relapsed and 1.08% developed epilepsy. There were significantly different in the rate of relapses and development of epilepsy between the two groups (P<0.05). Conclusions There are the risks of relapse and development of epilepsy in BICE patients. Convulsions ≥ 2 times and ≥ 5 minutes may be the risk factors of relapse and development of epilepsy.