近年来随着表观遗传研究的发展，染色质重塑对于基因表达的调控也越来越受到关注。其中SWI/SNF作为最为重要的一种染色质重塑复合物，其在种属间具有较高的保守性，通过结合相应的DNA序列，改变染色质局部形态，从而调控基因的表达。SWI/SNF染色质重塑复合物及其主要功能亚基在心脏发育、心脏功能整合及心肌病理性重构调控过程中均具有重要意义，且已经取得了众多突破性研究成果。这些研究结果为心脏疾病的发生发展机制提供了一种全新的理论与实验支持。文章综述SWI/SNF染色质重塑复合物在心脏发育及病理性重构中的研究进展。

With the rapid development of epigenetics, the importance of gene transcription regulated by chromatin remodeling has been noticed recently. The SWI/SNF chromatin remodeling complex has been identified as the most crucial complex in gene regulation with highly conserved structure among species, which alter the activities of genes by shifting the microstructure of DNA, regulating gene expression. A series studies have proved that SWI/SNF chromatin remodeling complex and the main functions of the subunitstook parts in the procedure of heart development, functional mature and pathological remodeling, and have made several breakthroughs. These findings provide a new theoretical and experimental support for the occurrence and development of heart disease.This article aims to review the research progress of SWI/SNF chromatin remodeling complex in regulating heart development and pathological remodeling.