双酚A 与女童性早熟的关系

吴海瑛; 陈临琪; 汪维鹏; 王凤云; 陈秀丽; 谢蓉蓉; 陈婷; 何光照

doi:10.3969 j.issn.1000-3606.2015.02.014

临床儿科杂志 >

2015 , Vol. 33 >Issue 2: 155

DOI: https://doi.org/10.3969 j.issn.1000-3606.2015.02.014

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双酚A 与女童性早熟的关系

吴海瑛 ,
陈临琪 ,
汪维鹏 ,
王凤云 ,
陈秀丽 ,
谢蓉蓉 ,
陈婷 ,
何光照

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1. 苏州大学附属儿童医院( 江苏苏州　215003)；2. 苏州大学药学院 ( 江苏苏州　215000)

收稿日期: 2015-02-15

网络出版日期: 2015-02-15

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A study of bisphenol A and precocious puberty in 6-8 years old girls

WU Haiying ,
CHEN Linqi ,
Wang Weipeng ,
WANG Fengyun ,
CHEN Xiuli ,
XIE Rongrong ,
CHEN Ting ,
HE Guangzhao

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1.Department of Endocrinology， Children’s Hospital Affiliated to Soochow University，Suzhou 215003，Jiangsu，China; 2.College of Pharmaceutical Science, Soochow University，Suzhou 215000，Jiangsu，China

Received date: 2015-02-15

Online published: 2015-02-15

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摘要

目的　探讨双酚A(BPA)与女童性早熟的关系。方法　选择2012年8月至12月就诊的103例6~8岁性早熟女童，根据性早熟分类标准分为特发性中枢性性早熟(ICPP)组(n=47)及单纯乳房发育(PT)组(n=56)，选取同期同年龄乳房未发育女童53例为正常对照组。高效液相色谱串联质谱法(HPLC-MS-MS)测定血清BPA，酶联免疫法测定血清Kisspeptin，化学发光法测定血清性激素，比较和分析三组间的差异。结果　ICPP组和PT组的血清BPA检出率高于对照组，ICPP组血清BPA水平高于PT组及对照组，差异有统计学意义(P均<0.05)；ICPP组血清Kisspeptin水平也高于PT组及对照组，差异有统计学意义(P均<0.05)；ICPP组血清黄体生成素(LH)峰值及LH/卵泡刺激素(FSH)比值高于PT组，ICPP组及PT组血清雌二醇(E2)水平高于对照组，差异有统计学意义(P均<0.05)。三组的血清BPA水平与E2、LH峰值及LH/FSH比值有相关性(P<0.05)，与血清Kisspeptin水平及FSH峰值无相关性(P>0.05)。结论　BPA与女童ICPP发生有一定的相关性。

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吴海瑛 , 陈临琪 , 汪维鹏 , 王凤云 , 陈秀丽 , 谢蓉蓉 , 陈婷 , 何光照 . 双酚A 与女童性早熟的关系[J]. 临床儿科杂志, 2015 , 33(2) : 155 . DOI: 10.3969 j.issn.1000-3606.2015.02.014

Abstract

　Objective　To study the relationship between bisphenol A and precocious puberty in 6-8 years girls. Methods Atotal of 103 girls aged 6-8 years with precocious puberty in our Endocrine clinic from August to December 2012 were selected. According to the classification standard of precocious puberty, girls are divided into idiopathic central precocious puberty (ICPP) group (n=47) and permature thelarche (PT) group (n=56), 53 girls with no puberty development were chosen as control group. BPA concentrations were determined with HPLC-MS-MS, sex hormones were determined with chemiluminescence method and Kisspeptin concentrations were determined with ELISA, then the differences among the three groups were compared and the relationships between bisphenol A and sex hormones and Kisspeptin were analyzed. Results The BPA relevance ratio and concentration in ICPP group were higher than those of PT group and control group (P<0.05). The peak concentration of LH and LH/FSH in ICPP group were higher than those of PT group (P<0.05). The concentration of E2 in ICPP group and PT group were higher than that of control group (P<0.05). The concentration of Kisspeptin in ICPP group was higher than that of PT group and control group (P<0.05). There were no relationship between the concentrations of bisphenol A and Kisspeptin and FSH peak concentration (P>0.05). There were correlations between the concentrations of BPA and E2 and LH peak concentration and LH/FSH
(P<0.05). Conclusions There is a certain correlation between the concentrations of BPA and ICPP.

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