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ILC2 参与哮喘发病机制的研究进展

  • 蒋芹
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  • 1 . 上海交通大学医学院(上海 200233);2 . 上海交通大学附属第六人民医院儿科(上海 200233)

收稿日期: 2017-02-15

  网络出版日期: 2017-02-15

Progress on roles of type 2 innate lymphoid cells in the pathogenesis of asthma

  • JIANG Qin
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  • 1. Shanghai Jiao Tong University of Medicine, Shanghai 200233, China; 2.Department of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233 , China

Received date: 2017-02-15

  Online published: 2017-02-15

摘要

Ⅱ型固有淋巴样细胞(ILC2)是ILC家族中最近发现的一个新成员。抗原暴露后,ILC2被上皮细胞来源的细胞 因子、脂质递质和肿瘤坏死因子家族成员TL1A激活,促进气道结构细胞和免疫细胞反应。ILC2是固有免疫应答的关键 部分,且与支气管哮喘的发病机制有关。文章就ILC2参与哮喘发病机制的研究进展作了综述。

本文引用格式

蒋芹 . ILC2 参与哮喘发病机制的研究进展[J]. 临床儿科杂志, 2017 , 35(2) : 148 . DOI: 10.3969/j.issn.1000-3606.2017.02.017

Abstract

Type 2 innate lymphoid cell (ILC2) is a new member of the innate lymphoid cell family discovered recently. After being exposed to antigens, ILC2 was activated by epithelial cell-derived cytokines, lipid mediators and TNF family member TL1A to promote structural and immune cell responses in the airways. These cells are critical components of the innate immune response involved in the pathogenesis of asthma. This paper summarizes the progress on the roles of type 2 innate lymphoid cells in the pathogenesis of asthma.
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