目的　探讨新生儿李斯特菌败血症的临床特点，提高对新生儿李斯特菌败血症的认识。方法　回顾性分析 2011年1月－2016年6月诊治的9例经血培养确诊的新生儿李斯特菌败血症的临床特点。结果　9例均为早产儿，剖宫产； 临床表现主要为发绀（7例）、发热（5例）、气促（4例）、肌张力减弱（4例）、呼吸窘迫（3例）等。 9例新生儿血培养均检出李 斯特菌， 3例在痰液、 1例在脑脊液中同时培养出李斯特菌；药敏试验显示，李斯特菌对氨苄西林、青霉素和复方新诺明敏 感率最高。 9例均在血培养确诊李斯特菌败血症后调整抗感染药物治疗，均痊愈或好转出院。结论　新生儿李斯特菌感染 是一种严重的感染性疾病。对有发热症状的孕妇，应警惕李斯特菌感染。尽早行病原学检测和目标性治疗有助于改善预后。

　Objective　To explore the clinical features of neonatal septicemia caused by Lester. Methods　The clinical features of septicemia caused by Lester bacteria in 9 neonates confirmed by blood culture during from January 2011 to June 2016 were retrospectively analyzed. Results　All of the 9 cases were premature and cesarean delivery. The main clinical manifestations were cyanosis (7 cases), fever (5 cases), anhelation (4 cases), hypomyotonia (4 cases), and respiratory distress (3 cases). Blood cultures in 9 cases were detected Lester bacteria with 3 cases found in sputum and 1 case in both sputum and cerebrospinal fluid. Drug sensitivity test showed that Lester bacteria were sensitive to ampicillin, penicillin, and sulfamethoxazole. All of the 9 cases adjusted anti-infective medications after the diagnosis of Lester septicemia by blood culture, and all of them were cured or improved, and discharged. Conclusion　Neonatal Lester infection is a serious infectious disease. Fever in pregnant women should alert clinicians to Lester infection. Early detection of pathogens and targeted treatment can help improve prognosis.