目的　探讨具有人白细胞抗原B*1502(HLA-B*15:02)不同基因型和年龄对抽搐或癫痫患儿血浆同型半胱 氨酸(Hcy )浓度的影响，研究患儿血浆Hcy浓度的影响因素，以减少血浆Hcy增高所致的潜在致病风险。方法　选取2015 年10月至2016年6月间检测HLA-B*15:02基因型的抽搐或癫痫患儿15例，比较不同基因型患儿的血浆Hcy浓度；并将后 者对应患儿年龄作线性回归分析。结果　血浆Hcy平均浓度在未携带HLA-B*15:02基因患儿中为(8.38±4.23)μmol/L， 在携带HLA-B*15:02基因患儿中为(13.03±0.97)μmol/L，携带者明显高于未携带者。随着患儿年龄增加，血浆Hcy浓 度有增高趋势 (r2=0.29, P＜0.05 )。结论　HLA-B*15:02基因携带者和较大年龄抽搐或癫痫患儿有发生血Hcy增高的倾 向，增加患儿潜在致病风险。HLA-B*15:02基因型和年龄可预测抽搐患儿血浆Hcy浓度变化倾向。

　Objective　To explore the effect of human leukocyte antigen B* genotype and age on serum homocysteine (Hcy) levels in children with seizures or epilepsy. Methods　Fifteen children with seizures or epilepsy in whom HLA-B*15:02 genotype was detected during October 2015 to June 2016 were included. The plasma Hcy concentration in children with different genotypes was compared. The association of Hcy concentration and age was performed by linear-regression analysis. Results　The mean concentration of Hcy was 8.38±4.23 μmol/L in children not carrying HLA-B*15:02 gene, which was obviously higher than that in children carrying HLA-B*15:02 gene 13.03±0.97 μmol/L (P<0.05). The Hcy concentration increased with the age (r2 =0.29, P<0.05). Conclusions　Elder children with seizures or epilepsy carrying HLA-B*15:02 gene tend to have higher Hcy concentration and increased potential risk of disease. HLA-B*15:02 gene type and age  can predict the changes of Hcy concentration in children with convulsions.