目的　评价妊娠期高血压与胎儿先天性心脏发病的关系。方法　通过数据库（PubMed、Elsevier和Web of Science）检索妊娠期高血压与胎儿先天性心脏病发病相关的文献。利用Stata软件对其进行综合分析。结果　纳入13项病 例对照和10项队列研究。妊娠期高血压增加胎儿先天性心脏病发病风险（RR=1.65，95%CI：1.50~1.83）；亚组分析显 示，妊娠期高血压治疗组和未治疗组，均会增加胎儿先天性心脏病发病风险（RR=2.11，95%CI：1.72~2.58；RR=1.61， 95%CI：1.34~1.94）；在高血压治疗组中，钙离子通道阻滞剂、肾上腺素受体阻滞剂和利尿剂不会增加胎儿先天性心脏病 发病风险（P＞0.05），β 受体阻滞剂和血管紧张素转换酶抑制剂者均会增加胎儿先天性心脏病发病风险（P＜0.05）。 结 论　妊娠期高血压增加胎儿先天性心脏病发病风险。

　Objective　Systematical evaluation of studies published abroad on pregnancy induced hypertension and incidence of congenital heart diseases (CHDs), to investigate the relationship between pregnancy induced hypertension and the risk of CHDs morbidity. Methods　Studies of pregnancy induced hypertension and CHDs were identified by searching major electronic databases (PubMed, Elsevier and Web of Science) by the medical subject headings and keywords without language restriction. Stata was conducted to determine the risk of CHDs related to pregnancies induced hypertension. Results　Thirteen (13) case-control and 10 cohort studies were identified. Pregnancy induced hypertension was associated with an increased risk of CHDs morbidity (RR=1.65，95%CI: 1.50~1.83). Subgroup analysis showed that both of the pregnancy hypertension treated group and the untreated group increased the risk of CHDs morbidity (RR=2.11，95% CI: 1.72~2.58; RR=1.61，95% CI：1.34~1.94). Calcium channel blockers, adrenergic receptor blockers and diuretics did not increase the risk of CHDs morbidity (P＞0.05), β-blockers and angiotensin-converting enzyme inhibitor increased the risk of CHDs morbidity (P＜0.05). Conclusions　 Pregnancies induced hypertension increased risk of CHDs morbidity.