Journal of Clinical Pediatrics ›› 2022, Vol. 40 ›› Issue (1): 67-.doi: 10.12372/jcp.2022.21e0627

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Research progress of pediatric sepsis caused by carbapenem-resistant Klebsiella pneumoniae

Reviewer: LI Jiashan, Reviser: ZHAO Ruiqiu   

  1. Department of Pediatric Infection, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014, China
  • Online:2022-01-15 Published:2022-01-11

Abstract: In recent years, the resistance of gram-negative bacteria to antibiotics has reached a critical level, and the detection rate of carbapenem-resistant Klebsiella pneumoniae (CRKP) in pediatric wards in many countries has been increasing year by year. CRKP sepsis has an insidious onset and lacks specific clinical manifestations. However, CRKP sepsis is highly pathogenic, progresses rapidly, and is prone to multiple organ failure, which can endanger the lives of children. Carbapenem antibiotics are still the main treatment for CRKP infection, and new antibiotics are also being studied. This article reviews the clinical research progress of CRKP sepsis.

Key words: carbapenem resistance; Klebsiella pneumoniae; bloodstream infection; child