Journal of Clinical Pediatrics ›› 2023, Vol. 41 ›› Issue (7): 543-548.doi: 10.12372/jcp.2023.22e0853

• Original article • Previous Articles     Next Articles

The role of ELABELA/Apelin-APJ pathway in cardiovascular development

Reviewer: YANG Junjie1, Reviser: SUN Kun2   

  1. 1. Yuying Children's Hospital, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China
    2. Department of Pediatric Cardiovascular, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Received:2022-06-20 Online:2023-07-15 Published:2023-07-05

Abstract:

Congenital heart disease is the commonest birth defect and is closely related to cardiovascular development during the embryonic period. ELABELA/Apelin-APJ pathway mainly contains two peptide ligands, ELABELA and Apelin, as well as their common receptor APJ. It is known that ELABELA/Apelin-APJ pathway is involved in many physiological and pathological processes and is closely related to the occurrence of many disease. In recent years, the relationship between the ELABELA/Apelin-APJ pathway and cardiovascular development has received extensive attention. This article mainly summarizes and compares the powerful regulatory effects of the ELABELA/Apelin-APJ pathway on cardiovascular development, aiming to reveal the role of the two pathways in different stages of cardiac development and the great significance in preventing congenital cardiovascular malformation.

Key words: ELABELA/Apelin-APJ pathway, embryonic stem cell, cardiomyocyte differentiation