Journal of Clinical Pediatrics ›› 2023, Vol. 41 ›› Issue (10): 675-679.doi: 10.12372/jcp.2023.22e1648

• Neonatal Disease • Previous Articles     Next Articles

Related factors affecting delayed thyroid stimulating hormone elevation in preterm infants with gestational age <34 weeks

LU Xiaoyan1, CHEN Shaohong2, CHEN Yingying1, ZHOU Wenjun1, ZHOU Chan1, SONG Yan3, LI Luquan3, TANG Wenyan1()   

  1. 1. Department of Neonatology, Jiangxi Maternal and Child Health Hospital, Nanchang 330006, Jiangxi, China
    2. Department of Children's health, Jiangxi Maternal and Child Health Hospital, Nanchang 330006, Jiangxi, China
    3. Jiangxi Hospital Affiliated to Children’s Hospital of Chongqing Medical University, Nanchang 330006, Jiangxi, China
  • Received:2022-12-13 Online:2023-10-15 Published:2023-10-08

Abstract:

Objective To evaluate the related factors of delayed thyroid stimulating hormone elevation (dTSH) in premature infants with gestational age <34 weeks. Methods The clinical data, preliminary screening and venous blood thyroid stimulating hormone (TSH) results at 15-28d after birth of preterm infants with gestational age <34 weeks born in Jiangxi Maternal and Child Health Hospital and admitted to intensive care unit from March 2020 to September 2021 were retrospectively analyzed. Results A total of 441 preterm infants (253 boys and 188 girls) with gestational age <34 weeks were included, with an average gestational age of (30.0±2.0) weeks. There were 17 cases of dTSH (3.9%), including 7 cases of transient hyperthyrotropinemia and 10 cases of congenital hypothyroidism (CH). The TSH level in dTSH group was higher than that in normal group at first screening and 15 to 28 days after birth, and the difference was statistically significant (P<0.05). Multivariate logistic regression analysis showed that dopamine use, low birth weight and 5-minute Apgar score <7 were independent risk factors for dTSH development (P<0.05). Conclusions Preterm infants with gestational age <34 weeks may present with dTSH. Low birth weight, 5-minute low Apgar score, and use of dopamine are more likely to present dTSH. Attention should be paid to dynamic monitoring of thyroid function in preterm infants.

Key words: thyroid stimulating hormone, delayed thyroid stimulating hormone elevation, newborn screening, premature infant