儿科重症监护病房获得性肌无力的研究进展

doi:10.12372/jcp.2026.26e0158

Abstract

Abstract:

Intensive care unit-acquired weakness (ICU-AW) is a secondary neuromuscular syndrome occurring during critical illness, mainly manifesting as new-onset symmetrical limb weakness, muscle atrophy, and difficulty weaning from ventilation. This condition is well recognized in adult patients. However, there are few reports of ICU-AW in critically ill children, and awareness of the disease remains inadequate in the pediatric intensive care unit (PICU). Therefore, this article reviews the pediatric literature on ICU-AW and comprehensively summarizes the current academic understanding of pediatric ICU-AW in terms of epidemiology, risk factors, pathophysiology, diagnostic criteria and methods, and prevention and treatment. At this stage, research on pediatric ICU-AW is still insufficient with no unified diagnostic criteria, indicating that further clinical studies are required to deepen and unify the understanding of this disease. Reducing the risk factors for PICU-AW, as well as early mobilization, reduced sedation, and neuromuscular electrical stimulation therapy, may be effective measures for the prevention and treatment of PICU-AW.

Key words: pediatric, intensive care unit-acquired weakness, critical illness polyneuropathy, critical illness myopathy, clinical features

CLC Number:

DING Qiuyuan, ZHOU Liang. Research progress of pediatric intensive care unit-acquired weakness[J].Journal of Clinical Pediatrics, 2026, 44(8): 755-762.

Figures/Tables 1

References 39

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项目	危重病性多发性神经病	危重病性肌病
临床特征	肌力减弱，腱反射减弱或消失。可能出现远端感觉丧失（大/小神经纤维受累）	肌肉明显萎缩，但腱反射正常
神经电生理检查	神经源性损害。①神经传导：CMAPs和SNAPs波幅降低；②肌电图：纤颤电位（急性失神经表现）	肌源性损害。①神经传导：CMAPs波幅降低，感觉神经传导正常；②肌电图：短时限、多相运动单位电位
肌肉/神经活检	神经纤维水肿/肿胀，伴有轴突变性	Ⅱ型肌纤维萎缩。粗肌丝（肌球蛋白）丢失（特征性但非总是可见）

Research progress of pediatric intensive care unit-acquired weakness

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