Abstract: 　Objective　To summarize the clinical and biological characteristics and to analyze the prognosis of childhood lymphoma. Methods　Clinical data of 60 patients diagnosed as lymphoma during the past ten years were retrospectively studied. All cases were classified according to the WHO classification criteria of lymphoma and the St. Jude staging system. Results　Of all the 60 patients, the ratio of male to female was 2.5: 1. The median age was 8 years old (range from 6 months to 15 years). Localized mass was the most common chief complaint for first consultation accounting for 35.0%。 The proportion of the bone marrow and central nervous system involvement was 63.3% and 6.7%, respectively. Hodgkin lymphoma (HL) and non- Hodgkin lymphoma (NHL) counted for 8.3% and 91.7%, respectively. All HL were classified as CHL. As to NHL, LBL, BL/ B-ALL, ALCL, and DLBCL were the main types. According to St. Jude staging, the advanced stage accounted for 95.0%. There were 8 cases with progressive disease/relapse with median time of 14 months (ranged from 6 months to 84 months). 6. In all patients, the 5-year anticipated overall survival (OS) rate was (78%±6%); the 5-year OS for HL and NHL were 100% vs (76%±8%). The survival rate of the two groups showed no significant difference (P=0.270). Cox multivariate analysis indicated that sex (P=0.038) was independent prognostic factors. Conclusions　Pediatric lymphoma occurred more in male than in female, peaked at school age. The main histologic type was NHL. Most patients were diagnosed as advanced stage. By gender, female is a poor factor that affects prognosis.