›› 2018, Vol. 36 ›› Issue (8): 602-.doi: 10.3969/j.issn.1000-3606.2018.08.009

Previous Articles     Next Articles

Utility of blink reflexes in subtyping of inherited polyneuropathy

 SUN Ruidi1,WANG Hengdong2, JIANG Jun1   

  1. Department of Electrophysiology, 1.Wuhan Children Hospital Wuhan 421000, Hubei, China; 2. Hubei Taihe Hospital, Wuhan 442008, Hubei, China
  • Received:2018-08-15 Online:2018-08-15 Published:2018-08-15

Abstract:  Objective To investigate the utility of R1 latency of blink reflexes in typing of inherited polyneuropathy: Charcot-Marie-Tooth (CMT). Methods Patients diagnosed with CMT by a genetic test underwent blink reflex testing and extremity NCS were retrospectively analyzed. Blink reflex R1 latency, extremity NCS, and severity were compared between demyelinating subtypes and axonal subtypes. Results We included 24 demyelinating (14 males and 10 females) and 12 axonal (6 males and 6 females) CMT patients. R1-latency in demyelinating CMT group (14.41±0.73 ms) were longer than that in axonal CMT group (11.39±0.89 ms) (P<0.01). R1-latency were all >13 ms in demyelinating CMT group and ≤13 ms in axonal CMT group. Conclusions Blink reflex test is reliable for identification of inherited demyelinating polyneuropathy regardless of severity and can guide genetic testing.